Structural basis of substrate recognition and thermal protection by a small heat shock protein

Structural insights into the small heat shock proteins (sHsps) complexes with their substrates are sparse. Here, cryo-EM structure of a plastid sHsp, Hsp21, in complex with a bona fide substrate 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), suggests the anti-aggregation mechanism employed by sHsps...

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Autores principales: Chuanyang Yu, Stephen King Pong Leung, Wenxin Zhang, Louis Tung Faat Lai, Ying Ki Chan, Man Chit Wong, Samir Benlekbir, Yong Cui, Liwen Jiang, Wilson Chun Yu Lau
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/09be49c4dc4c4d6382cb857c08b53fd4
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Sumario:Structural insights into the small heat shock proteins (sHsps) complexes with their substrates are sparse. Here, cryo-EM structure of a plastid sHsp, Hsp21, in complex with a bona fide substrate 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), suggests the anti-aggregation mechanism employed by sHsps.