Structural basis of substrate recognition and thermal protection by a small heat shock protein

Structural insights into the small heat shock proteins (sHsps) complexes with their substrates are sparse. Here, cryo-EM structure of a plastid sHsp, Hsp21, in complex with a bona fide substrate 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), suggests the anti-aggregation mechanism employed by sHsps...

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Autores principales:	Chuanyang Yu, Stephen King Pong Leung, Wenxin Zhang, Louis Tung Faat Lai, Ying Ki Chan, Man Chit Wong, Samir Benlekbir, Yong Cui, Liwen Jiang, Wilson Chun Yu Lau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09be49c4dc4c4d6382cb857c08b53fd4
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spelling	oai:doaj.org-article:09be49c4dc4c4d6382cb857c08b53fd42021-12-02T15:45:24ZStructural basis of substrate recognition and thermal protection by a small heat shock protein10.1038/s41467-021-23338-y2041-1723https://doaj.org/article/09be49c4dc4c4d6382cb857c08b53fd42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23338-yhttps://doaj.org/toc/2041-1723Structural insights into the small heat shock proteins (sHsps) complexes with their substrates are sparse. Here, cryo-EM structure of a plastid sHsp, Hsp21, in complex with a bona fide substrate 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), suggests the anti-aggregation mechanism employed by sHsps.Chuanyang YuStephen King Pong LeungWenxin ZhangLouis Tung Faat LaiYing Ki ChanMan Chit WongSamir BenlekbirYong CuiLiwen JiangWilson Chun Yu LauNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chuanyang Yu Stephen King Pong Leung Wenxin Zhang Louis Tung Faat Lai Ying Ki Chan Man Chit Wong Samir Benlekbir Yong Cui Liwen Jiang Wilson Chun Yu Lau Structural basis of substrate recognition and thermal protection by a small heat shock protein
description	Structural insights into the small heat shock proteins (sHsps) complexes with their substrates are sparse. Here, cryo-EM structure of a plastid sHsp, Hsp21, in complex with a bona fide substrate 1-deoxy-D-xylulose 5-phosphate synthase (DXPS), suggests the anti-aggregation mechanism employed by sHsps.
format	article
author	Chuanyang Yu Stephen King Pong Leung Wenxin Zhang Louis Tung Faat Lai Ying Ki Chan Man Chit Wong Samir Benlekbir Yong Cui Liwen Jiang Wilson Chun Yu Lau
author_facet	Chuanyang Yu Stephen King Pong Leung Wenxin Zhang Louis Tung Faat Lai Ying Ki Chan Man Chit Wong Samir Benlekbir Yong Cui Liwen Jiang Wilson Chun Yu Lau
author_sort	Chuanyang Yu
title	Structural basis of substrate recognition and thermal protection by a small heat shock protein
title_short	Structural basis of substrate recognition and thermal protection by a small heat shock protein
title_full	Structural basis of substrate recognition and thermal protection by a small heat shock protein
title_fullStr	Structural basis of substrate recognition and thermal protection by a small heat shock protein
title_full_unstemmed	Structural basis of substrate recognition and thermal protection by a small heat shock protein
title_sort	structural basis of substrate recognition and thermal protection by a small heat shock protein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/09be49c4dc4c4d6382cb857c08b53fd4
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_version_	1718385732591026176

Structural basis of substrate recognition and thermal protection by a small heat shock protein

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