Psychological and biological resilience modulates the effects of stress on epigenetic aging

Abstract Our society is experiencing more stress than ever before, leading to both negative psychiatric and physical outcomes. Chronic stress is linked to negative long-term health consequences, raising the possibility that stress is related to accelerated aging. In this study, we examine whether re...

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Autores principales:	Zachary M. Harvanek, Nia Fogelman, Ke Xu, Rajita Sinha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/09bfeefc66eb43ebbf544bfe40048c58
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spelling	oai:doaj.org-article:09bfeefc66eb43ebbf544bfe40048c582021-11-28T12:09:24ZPsychological and biological resilience modulates the effects of stress on epigenetic aging10.1038/s41398-021-01735-72158-3188https://doaj.org/article/09bfeefc66eb43ebbf544bfe40048c582021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01735-7https://doaj.org/toc/2158-3188Abstract Our society is experiencing more stress than ever before, leading to both negative psychiatric and physical outcomes. Chronic stress is linked to negative long-term health consequences, raising the possibility that stress is related to accelerated aging. In this study, we examine whether resilience factors affect stress-associated biological age acceleration. Recently developed “epigenetic clocks” such as GrimAge have shown utility in predicting biological age and mortality. Here, we assessed the impact of cumulative stress, stress physiology, and resilience on accelerated aging in a community sample (N = 444). Cumulative stress was associated with accelerated GrimAge (P = 0.0388) and stress-related physiologic measures of adrenal sensitivity (Cortisol/ACTH ratio) and insulin resistance (HOMA). After controlling for demographic and behavioral factors, HOMA correlated with accelerated GrimAge (P = 0.0186). Remarkably, psychological resilience factors of emotion regulation and self-control moderated these relationships. Emotion regulation moderated the association between stress and aging (P = 8.82e−4) such that with worse emotion regulation, there was greater stress-related age acceleration, while stronger emotion regulation prevented any significant effect of stress on GrimAge. Self-control moderated the relationship between stress and insulin resistance (P = 0.00732), with high self-control blunting this relationship. In the final model, in those with poor emotion regulation, cumulative stress continued to predict additional GrimAge Acceleration even while accounting for demographic, physiologic, and behavioral covariates. These results demonstrate that cumulative stress is associated with epigenetic aging in a healthy population, and these associations are modified by biobehavioral resilience factors.Zachary M. HarvanekNia FogelmanKe XuRajita SinhaNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Zachary M. Harvanek Nia Fogelman Ke Xu Rajita Sinha Psychological and biological resilience modulates the effects of stress on epigenetic aging
description	Abstract Our society is experiencing more stress than ever before, leading to both negative psychiatric and physical outcomes. Chronic stress is linked to negative long-term health consequences, raising the possibility that stress is related to accelerated aging. In this study, we examine whether resilience factors affect stress-associated biological age acceleration. Recently developed “epigenetic clocks” such as GrimAge have shown utility in predicting biological age and mortality. Here, we assessed the impact of cumulative stress, stress physiology, and resilience on accelerated aging in a community sample (N = 444). Cumulative stress was associated with accelerated GrimAge (P = 0.0388) and stress-related physiologic measures of adrenal sensitivity (Cortisol/ACTH ratio) and insulin resistance (HOMA). After controlling for demographic and behavioral factors, HOMA correlated with accelerated GrimAge (P = 0.0186). Remarkably, psychological resilience factors of emotion regulation and self-control moderated these relationships. Emotion regulation moderated the association between stress and aging (P = 8.82e−4) such that with worse emotion regulation, there was greater stress-related age acceleration, while stronger emotion regulation prevented any significant effect of stress on GrimAge. Self-control moderated the relationship between stress and insulin resistance (P = 0.00732), with high self-control blunting this relationship. In the final model, in those with poor emotion regulation, cumulative stress continued to predict additional GrimAge Acceleration even while accounting for demographic, physiologic, and behavioral covariates. These results demonstrate that cumulative stress is associated with epigenetic aging in a healthy population, and these associations are modified by biobehavioral resilience factors.
format	article
author	Zachary M. Harvanek Nia Fogelman Ke Xu Rajita Sinha
author_facet	Zachary M. Harvanek Nia Fogelman Ke Xu Rajita Sinha
author_sort	Zachary M. Harvanek
title	Psychological and biological resilience modulates the effects of stress on epigenetic aging
title_short	Psychological and biological resilience modulates the effects of stress on epigenetic aging
title_full	Psychological and biological resilience modulates the effects of stress on epigenetic aging
title_fullStr	Psychological and biological resilience modulates the effects of stress on epigenetic aging
title_full_unstemmed	Psychological and biological resilience modulates the effects of stress on epigenetic aging
title_sort	psychological and biological resilience modulates the effects of stress on epigenetic aging
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/09bfeefc66eb43ebbf544bfe40048c58
work_keys_str_mv	AT zacharymharvanek psychologicalandbiologicalresiliencemodulatestheeffectsofstressonepigeneticaging AT niafogelman psychologicalandbiologicalresiliencemodulatestheeffectsofstressonepigeneticaging AT kexu psychologicalandbiologicalresiliencemodulatestheeffectsofstressonepigeneticaging AT rajitasinha psychologicalandbiologicalresiliencemodulatestheeffectsofstressonepigeneticaging
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Psychological and biological resilience modulates the effects of stress on epigenetic aging

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