Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date

Navika D Shukla, Allen L Ho, Arjun V Pendharkar, Eric S Sussman, Casey H Halpern Department of Neurosurgery, Stanford University, Stanford, CA, USA Abstract: Medically intractable epilepsy is associated with increased morbidity and mortality. For those with focal epilepsy and correlated electrophy...

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Autores principales: Shukla ND, Ho AL, Pendharkar AV, Sussman ES, Halpern CH
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Lenguaje:EN
Publicado: Dove Medical Press 2017
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Acceso en línea:https://doaj.org/article/09c0a920fec44df0800bea39d5089b54
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spelling oai:doaj.org-article:09c0a920fec44df0800bea39d5089b542021-12-02T00:40:46ZLaser interstitial thermal therapy for the treatment of epilepsy: evidence to date1178-2021https://doaj.org/article/09c0a920fec44df0800bea39d5089b542017-09-01T00:00:00Zhttps://www.dovepress.com/laser-interstitial-thermal-therapy-for-the-treatment-of-epilepsy-evide-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Navika D Shukla, Allen L Ho, Arjun V Pendharkar, Eric S Sussman, Casey H Halpern Department of Neurosurgery, Stanford University, Stanford, CA, USA Abstract: Medically intractable epilepsy is associated with increased morbidity and mortality. For those with focal epilepsy and correlated electrophysiological or radiographic features, open surgical resection can achieve high rates of seizure control, but can be associated with neurologic deficits and cognitive effects. Recent innovations have allowed for more minimally invasive methods of surgical seizure control such as magnetic resonance-guided laser interstitial therapy (MRgLITT). MRgLITT achieves the goal of ablating seizure foci while preserving neuropsychological function and offering real-time feedback and monitoring of tissue ablation. This review summarizes the utilization of MRgLITT for mesial temporal lobe epilepsy and other seizure disorders. Overall, the efficacy of MRgLITT is comparable to that of open surgery and offers a less invasive approach in patients with significantly less morbidity. Keywords: laser ablation, MRgLITT, mesial temporal lobe epilepsy, epilepsy surgery, corpus callostomyShukla NDHo ALPendharkar AVSussman ESHalpern CHDove Medical Pressarticlelaser ablationMRgLITTmesial temporal lobe epilepsyepilepsy surgerycorpus callostomyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2469-2475 (2017)
institution DOAJ
collection DOAJ
language EN
topic laser ablation
MRgLITT
mesial temporal lobe epilepsy
epilepsy surgery
corpus callostomy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle laser ablation
MRgLITT
mesial temporal lobe epilepsy
epilepsy surgery
corpus callostomy
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Shukla ND
Ho AL
Pendharkar AV
Sussman ES
Halpern CH
Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date
description Navika D Shukla, Allen L Ho, Arjun V Pendharkar, Eric S Sussman, Casey H Halpern Department of Neurosurgery, Stanford University, Stanford, CA, USA Abstract: Medically intractable epilepsy is associated with increased morbidity and mortality. For those with focal epilepsy and correlated electrophysiological or radiographic features, open surgical resection can achieve high rates of seizure control, but can be associated with neurologic deficits and cognitive effects. Recent innovations have allowed for more minimally invasive methods of surgical seizure control such as magnetic resonance-guided laser interstitial therapy (MRgLITT). MRgLITT achieves the goal of ablating seizure foci while preserving neuropsychological function and offering real-time feedback and monitoring of tissue ablation. This review summarizes the utilization of MRgLITT for mesial temporal lobe epilepsy and other seizure disorders. Overall, the efficacy of MRgLITT is comparable to that of open surgery and offers a less invasive approach in patients with significantly less morbidity. Keywords: laser ablation, MRgLITT, mesial temporal lobe epilepsy, epilepsy surgery, corpus callostomy
format article
author Shukla ND
Ho AL
Pendharkar AV
Sussman ES
Halpern CH
author_facet Shukla ND
Ho AL
Pendharkar AV
Sussman ES
Halpern CH
author_sort Shukla ND
title Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date
title_short Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date
title_full Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date
title_fullStr Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date
title_full_unstemmed Laser interstitial thermal therapy for the treatment of epilepsy: evidence to date
title_sort laser interstitial thermal therapy for the treatment of epilepsy: evidence to date
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/09c0a920fec44df0800bea39d5089b54
work_keys_str_mv AT shukland laserinterstitialthermaltherapyforthetreatmentofepilepsyevidencetodate
AT hoal laserinterstitialthermaltherapyforthetreatmentofepilepsyevidencetodate
AT pendharkarav laserinterstitialthermaltherapyforthetreatmentofepilepsyevidencetodate
AT sussmanes laserinterstitialthermaltherapyforthetreatmentofepilepsyevidencetodate
AT halpernch laserinterstitialthermaltherapyforthetreatmentofepilepsyevidencetodate
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