Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study

<h4>Background</h4> Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from...

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Autores principales:	Antonio Gimeno-Miguel, Kevin Bliek-Bueno, Beatriz Poblador-Plou, Jonás Carmona-Pírez, Antonio Poncel-Falcó, Francisca González-Rubio, Ignatios Ioakeim-Skoufa, Victoria Pico-Soler, Mercedes Aza-Pascual-Salcedo, Alexandra Prados-Torres, Luis Andrés Gimeno-Feliu, on behalf of the PRECOVID Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09c2a4c328724df08ba1d1fc9c321e25
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spelling	oai:doaj.org-article:09c2a4c328724df08ba1d1fc9c321e252021-11-25T06:10:58ZChronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study1932-6203https://doaj.org/article/09c2a4c328724df08ba1d1fc9c321e252021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589220/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from a population-based perspective and using data from electronic health records (EHR). <h4>Methods</h4> Retrospective, observational study in an open cohort analyzing all 68,913 individuals (mean age 44.4 years, 53.2% women) with SARS-CoV-2 infection between 15 June and 19 December 2020 using exhaustive electronic health registries. Patients were followed for 30 days from inclusion or until the date of death within that period. We performed multivariate logistic regression to analyze the association between each chronic disease and severe infection, based on hospitalization and all-cause mortality. <h4>Results</h4> 5885 (8.5%) individuals showed severe infection and old age was the most influencing factor. Congestive heart failure (odds ratio -OR- men: 1.28, OR women: 1.39), diabetes (1.37, 1.24), chronic renal failure (1.31, 1.22) and obesity (1.21, 1.26) increased the likelihood of severe infection in both sexes. Chronic skin ulcers (1.32), acute cerebrovascular disease (1.34), chronic obstructive pulmonary disease (1.21), urinary incontinence (1.17) and neoplasms (1.26) in men, and infertility (1.87), obstructive sleep apnea (1.43), hepatic steatosis (1.43), rheumatoid arthritis (1.39) and menstrual disorders (1.18) in women were also associated with more severe outcomes. <h4>Conclusions</h4> Age and specific cardiovascular and metabolic diseases increased the risk of severe SARS-CoV-2 infections in men and women, whereas the effects of certain comorbidities are sex specific. Future studies in different settings are encouraged to analyze which profiles of chronic patients are at higher risk of poor prognosis and should therefore be the targets of prevention and shielding strategies.Antonio Gimeno-MiguelKevin Bliek-BuenoBeatriz Poblador-PlouJonás Carmona-PírezAntonio Poncel-FalcóFrancisca González-RubioIgnatios Ioakeim-SkoufaVictoria Pico-SolerMercedes Aza-Pascual-SalcedoAlexandra Prados-TorresLuis Andrés Gimeno-Feliuon behalf of the PRECOVID GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonio Gimeno-Miguel Kevin Bliek-Bueno Beatriz Poblador-Plou Jonás Carmona-Pírez Antonio Poncel-Falcó Francisca González-Rubio Ignatios Ioakeim-Skoufa Victoria Pico-Soler Mercedes Aza-Pascual-Salcedo Alexandra Prados-Torres Luis Andrés Gimeno-Feliu on behalf of the PRECOVID Group Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
description	<h4>Background</h4> Clinical outcomes among COVID-19 patients vary greatly with age and underlying comorbidities. We aimed to determine the demographic and clinical factors, particularly baseline chronic conditions, associated with an increased risk of severity in COVID-19 patients from a population-based perspective and using data from electronic health records (EHR). <h4>Methods</h4> Retrospective, observational study in an open cohort analyzing all 68,913 individuals (mean age 44.4 years, 53.2% women) with SARS-CoV-2 infection between 15 June and 19 December 2020 using exhaustive electronic health registries. Patients were followed for 30 days from inclusion or until the date of death within that period. We performed multivariate logistic regression to analyze the association between each chronic disease and severe infection, based on hospitalization and all-cause mortality. <h4>Results</h4> 5885 (8.5%) individuals showed severe infection and old age was the most influencing factor. Congestive heart failure (odds ratio -OR- men: 1.28, OR women: 1.39), diabetes (1.37, 1.24), chronic renal failure (1.31, 1.22) and obesity (1.21, 1.26) increased the likelihood of severe infection in both sexes. Chronic skin ulcers (1.32), acute cerebrovascular disease (1.34), chronic obstructive pulmonary disease (1.21), urinary incontinence (1.17) and neoplasms (1.26) in men, and infertility (1.87), obstructive sleep apnea (1.43), hepatic steatosis (1.43), rheumatoid arthritis (1.39) and menstrual disorders (1.18) in women were also associated with more severe outcomes. <h4>Conclusions</h4> Age and specific cardiovascular and metabolic diseases increased the risk of severe SARS-CoV-2 infections in men and women, whereas the effects of certain comorbidities are sex specific. Future studies in different settings are encouraged to analyze which profiles of chronic patients are at higher risk of poor prognosis and should therefore be the targets of prevention and shielding strategies.
format	article
author	Antonio Gimeno-Miguel Kevin Bliek-Bueno Beatriz Poblador-Plou Jonás Carmona-Pírez Antonio Poncel-Falcó Francisca González-Rubio Ignatios Ioakeim-Skoufa Victoria Pico-Soler Mercedes Aza-Pascual-Salcedo Alexandra Prados-Torres Luis Andrés Gimeno-Feliu on behalf of the PRECOVID Group
author_facet	Antonio Gimeno-Miguel Kevin Bliek-Bueno Beatriz Poblador-Plou Jonás Carmona-Pírez Antonio Poncel-Falcó Francisca González-Rubio Ignatios Ioakeim-Skoufa Victoria Pico-Soler Mercedes Aza-Pascual-Salcedo Alexandra Prados-Torres Luis Andrés Gimeno-Feliu on behalf of the PRECOVID Group
author_sort	Antonio Gimeno-Miguel
title	Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
title_short	Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
title_full	Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
title_fullStr	Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
title_full_unstemmed	Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study
title_sort	chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 covid-19 confirmed cases in spain: a population-based cohort study
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/09c2a4c328724df08ba1d1fc9c321e25
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Chronic diseases associated with increased likelihood of hospitalization and mortality in 68,913 COVID-19 confirmed cases in Spain: A population-based cohort study

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