Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass spectrometry to characterize the proteolytic cleavage profile of viral and cellular proteins in vitro.

Guardado en:

Detalles Bibliográficos
Autores principales:	Bjoern Meyer, Jeanne Chiaravalli, Stacy Gellenoncourt, Philip Brownridge, Dominic P. Bryne, Leonard A. Daly, Arturas Grauslys, Marius Walter, Fabrice Agou, Lisa A. Chakrabarti, Charles S. Craik, Claire E. Eyers, Patrick A. Eyers, Yann Gambin, Andrew R. Jones, Emma Sierecki, Eric Verdin, Marco Vignuzzi, Edward Emmott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09cd9fa5dad54609b514710cffa2869d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:09cd9fa5dad54609b514710cffa2869d
record_format	dspace
spelling	oai:doaj.org-article:09cd9fa5dad54609b514710cffa2869d2021-12-02T18:48:11ZCharacterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential10.1038/s41467-021-25796-w2041-1723https://doaj.org/article/09cd9fa5dad54609b514710cffa2869d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25796-whttps://doaj.org/toc/2041-1723During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass spectrometry to characterize the proteolytic cleavage profile of viral and cellular proteins in vitro.Bjoern MeyerJeanne ChiaravalliStacy GellenoncourtPhilip BrownridgeDominic P. BryneLeonard A. DalyArturas GrauslysMarius WalterFabrice AgouLisa A. ChakrabartiCharles S. CraikClaire E. EyersPatrick A. EyersYann GambinAndrew R. JonesEmma SiereckiEric VerdinMarco VignuzziEdward EmmottNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bjoern Meyer Jeanne Chiaravalli Stacy Gellenoncourt Philip Brownridge Dominic P. Bryne Leonard A. Daly Arturas Grauslys Marius Walter Fabrice Agou Lisa A. Chakrabarti Charles S. Craik Claire E. Eyers Patrick A. Eyers Yann Gambin Andrew R. Jones Emma Sierecki Eric Verdin Marco Vignuzzi Edward Emmott Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
description	During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass spectrometry to characterize the proteolytic cleavage profile of viral and cellular proteins in vitro.
format	article
author	Bjoern Meyer Jeanne Chiaravalli Stacy Gellenoncourt Philip Brownridge Dominic P. Bryne Leonard A. Daly Arturas Grauslys Marius Walter Fabrice Agou Lisa A. Chakrabarti Charles S. Craik Claire E. Eyers Patrick A. Eyers Yann Gambin Andrew R. Jones Emma Sierecki Eric Verdin Marco Vignuzzi Edward Emmott
author_facet	Bjoern Meyer Jeanne Chiaravalli Stacy Gellenoncourt Philip Brownridge Dominic P. Bryne Leonard A. Daly Arturas Grauslys Marius Walter Fabrice Agou Lisa A. Chakrabarti Charles S. Craik Claire E. Eyers Patrick A. Eyers Yann Gambin Andrew R. Jones Emma Sierecki Eric Verdin Marco Vignuzzi Edward Emmott
author_sort	Bjoern Meyer
title	Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
title_short	Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
title_full	Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
title_fullStr	Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
title_full_unstemmed	Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
title_sort	characterising proteolysis during sars-cov-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/09cd9fa5dad54609b514710cffa2869d
work_keys_str_mv	AT bjoernmeyer characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT jeannechiaravalli characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT stacygellenoncourt characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT philipbrownridge characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT dominicpbryne characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT leonardadaly characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT arturasgrauslys characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT mariuswalter characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT fabriceagou characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT lisaachakrabarti characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT charlesscraik characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT claireeeyers characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT patrickaeyers characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT yanngambin characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT andrewrjones characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT emmasierecki characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT ericverdin characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT marcovignuzzi characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential AT edwardemmott characterisingproteolysisduringsarscov2infectionidentifiesviralcleavagesitesandcellulartargetswiththerapeuticpotential
_version_	1718377604154654720

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

Ejemplares similares