Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth

Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.

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Autores principales:	Sumeet Pal Singh, Sharan Janjuha, Theresa Hartmann, Özge Kayisoglu, Judith Konantz, Sarah Birke, Priyanka Murawala, Ezzaldin Ahmed Alfar, Kei Murata, Anne Eugster, Naoki Tsuji, Edward R. Morrissey, Michael Brand, Nikolay Ninov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09d63bb2e4484ac98df9ddecef7e0e11
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spelling	oai:doaj.org-article:09d63bb2e4484ac98df9ddecef7e0e112021-12-02T14:42:05ZDifferent developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth10.1038/s41467-017-00461-32041-1723https://doaj.org/article/09d63bb2e4484ac98df9ddecef7e0e112017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00461-3https://doaj.org/toc/2041-1723Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.Sumeet Pal SinghSharan JanjuhaTheresa HartmannÖzge KayisogluJudith KonantzSarah BirkePriyanka MurawalaEzzaldin Ahmed AlfarKei MurataAnne EugsterNaoki TsujiEdward R. MorrisseyMichael BrandNikolay NinovNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sumeet Pal Singh Sharan Janjuha Theresa Hartmann Özge Kayisoglu Judith Konantz Sarah Birke Priyanka Murawala Ezzaldin Ahmed Alfar Kei Murata Anne Eugster Naoki Tsuji Edward R. Morrissey Michael Brand Nikolay Ninov Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
description	Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.
format	article
author	Sumeet Pal Singh Sharan Janjuha Theresa Hartmann Özge Kayisoglu Judith Konantz Sarah Birke Priyanka Murawala Ezzaldin Ahmed Alfar Kei Murata Anne Eugster Naoki Tsuji Edward R. Morrissey Michael Brand Nikolay Ninov
author_facet	Sumeet Pal Singh Sharan Janjuha Theresa Hartmann Özge Kayisoglu Judith Konantz Sarah Birke Priyanka Murawala Ezzaldin Ahmed Alfar Kei Murata Anne Eugster Naoki Tsuji Edward R. Morrissey Michael Brand Nikolay Ninov
author_sort	Sumeet Pal Singh
title	Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
title_short	Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
title_full	Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
title_fullStr	Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
title_full_unstemmed	Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
title_sort	different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/09d63bb2e4484ac98df9ddecef7e0e11
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Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth

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