Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
Βeta-cells have recently been shown to be heterogeneous with regard to morphology and function. Here, the authors show that β-cells in zebrafish switch from proliferative to functional states with increasing time since β-cell birth, leading to functional and proliferative heterogeneity.
Guardado en:
Autores principales: | Sumeet Pal Singh, Sharan Janjuha, Theresa Hartmann, Özge Kayisoglu, Judith Konantz, Sarah Birke, Priyanka Murawala, Ezzaldin Ahmed Alfar, Kei Murata, Anne Eugster, Naoki Tsuji, Edward R. Morrissey, Michael Brand, Nikolay Ninov |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/09d63bb2e4484ac98df9ddecef7e0e11 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity
por: Ezzaldin Ahmed Alfar, et al.
Publicado: (2017) - Islets
-
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect.
por: Tomer Shlomi, et al.
Publicado: (2011) -
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
por: Martha Campbell-Thompson, et al.
Publicado: (2021) -
Islet Biology and Metabolism
por: Belinda Yau, et al.
Publicado: (2021)