ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair

Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I editing.

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Detalles Bibliográficos
Autores principales:	Sonia Jimeno, Rosario Prados-Carvajal, María Jesús Fernández-Ávila, Sonia Silva, Domenico Alessandro Silvestris, Martín Endara-Coll, Guillermo Rodríguez-Real, Judit Domingo-Prim, Fernando Mejías-Navarro, Amador Romero-Franco, Silvia Jimeno-González, Sonia Barroso, Valeriana Cesarini, Andrés Aguilera, Angela Gallo, Neus Visa, Pablo Huertas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09d9d77f3a254b6e952ffa2219df630e
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spelling	oai:doaj.org-article:09d9d77f3a254b6e952ffa2219df630e2021-12-02T15:16:10ZADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair10.1038/s41467-021-25790-22041-1723https://doaj.org/article/09d9d77f3a254b6e952ffa2219df630e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25790-2https://doaj.org/toc/2041-1723Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I editing.Sonia JimenoRosario Prados-CarvajalMaría Jesús Fernández-ÁvilaSonia SilvaDomenico Alessandro SilvestrisMartín Endara-CollGuillermo Rodríguez-RealJudit Domingo-PrimFernando Mejías-NavarroAmador Romero-FrancoSilvia Jimeno-GonzálezSonia BarrosoValeriana CesariniAndrés AguileraAngela GalloNeus VisaPablo HuertasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sonia Jimeno Rosario Prados-Carvajal María Jesús Fernández-Ávila Sonia Silva Domenico Alessandro Silvestris Martín Endara-Coll Guillermo Rodríguez-Real Judit Domingo-Prim Fernando Mejías-Navarro Amador Romero-Franco Silvia Jimeno-González Sonia Barroso Valeriana Cesarini Andrés Aguilera Angela Gallo Neus Visa Pablo Huertas ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
description	Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I editing.
format	article
author	Sonia Jimeno Rosario Prados-Carvajal María Jesús Fernández-Ávila Sonia Silva Domenico Alessandro Silvestris Martín Endara-Coll Guillermo Rodríguez-Real Judit Domingo-Prim Fernando Mejías-Navarro Amador Romero-Franco Silvia Jimeno-González Sonia Barroso Valeriana Cesarini Andrés Aguilera Angela Gallo Neus Visa Pablo Huertas
author_facet	Sonia Jimeno Rosario Prados-Carvajal María Jesús Fernández-Ávila Sonia Silva Domenico Alessandro Silvestris Martín Endara-Coll Guillermo Rodríguez-Real Judit Domingo-Prim Fernando Mejías-Navarro Amador Romero-Franco Silvia Jimeno-González Sonia Barroso Valeriana Cesarini Andrés Aguilera Angela Gallo Neus Visa Pablo Huertas
author_sort	Sonia Jimeno
title	ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
title_short	ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
title_full	ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
title_fullStr	ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
title_full_unstemmed	ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
title_sort	adar-mediated rna editing of dna:rna hybrids is required for dna double strand break repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/09d9d77f3a254b6e952ffa2219df630e
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ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair

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