A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study

Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto NakamuraDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, JapanBackground: Leber hereditary optic neuropathy (LHON) is a maternally inherited di...

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Autores principales:	Kurimoto T, Ueda K, Mori S, Sakamoto M, Yamada-Nakanishi Y, Matsumiya W, Nakamura M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Skin electrical stimulation Leber hereditary optic neuropathy Logarithm of minimum angle resolution Single-arm study Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/09daa241e5e442228fdede7d11e49841
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spelling	oai:doaj.org-article:09daa241e5e442228fdede7d11e498412021-12-02T05:56:21ZA study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study1177-5483https://doaj.org/article/09daa241e5e442228fdede7d11e498412019-05-01T00:00:00Zhttps://www.dovepress.com/a-study-protocol-for-evaluating-the-efficacy-and-safety-of-skin-electr-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto NakamuraDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, JapanBackground: Leber hereditary optic neuropathy (LHON) is a maternally inherited disease caused by three missense mutations of mitochondrial (mt) DNA, ie, m 3460 G>A, m 11778 G>A, or m 14484 T>C in the greater portion of LHON. m 11778 G>A mutation is especially observed in >90% of the cases in Japanese families. Although spontaneous remission of visual function infrequently occurs, effective treatment for LHON remains unestablished. Transcorneal electrical stimulation has been shown to be efficacious in individuals with optic neuropathy. However, due to potential risk of corneal damage, repeated treatments are not permissible. In this exploratory study, we will be conducting skin electrical stimulation (SES) as an intervention for patients with LHON having 11778 missense mutation and investigate effectiveness and safety of SES.Methods: This is a single-arm, prospective, open-label exploratory trial focused on patients with LHON having 11778 missense mutation. Eleven patients will be enrolled and receive six consecutive SES once every 2 weeks up to 10 weeks. The safety of the SES will be monitored with specular microscopy, slit-lamp biomicroscopy, fundus examinations, and the observation of facial skin. The primary outcome measure will be the averaged l ogarithm of minimum angle resolution (logMAR) converted visual acuity 1 week after the last SES. Secondary outcome measures include changes, in logMAR at 4 and 8 weeks after the last SES, such as visual field indices measured using Humphrey visual field and microperimetry-3, the thickness of peripapillary retinal fiber and macular ganglion cell complex, multifocal visual evoked potentials, critical flicker frequency, and color vision.Discussion: The results of this proposed proof-of-concept feasibility trial will help plan and execute a larger definitive trial to test SES as an effective strategy for LHON and related optic neuropathies and help establish a beneficial treatment for LHON.Keywords: skin electrical stimulation, Leber hereditary optic neuropathy, logarithm of minimum angle resolution, single-arm studyKurimoto TUeda KMori SSakamoto MYamada-Nakanishi YMatsumiya WNakamura MDove Medical PressarticleSkin electrical stimulationLeber hereditary optic neuropathyLogarithm of minimum angle resolutionSingle-arm studyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 897-904 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Skin electrical stimulation Leber hereditary optic neuropathy Logarithm of minimum angle resolution Single-arm study Ophthalmology RE1-994
spellingShingle	Skin electrical stimulation Leber hereditary optic neuropathy Logarithm of minimum angle resolution Single-arm study Ophthalmology RE1-994 Kurimoto T Ueda K Mori S Sakamoto M Yamada-Nakanishi Y Matsumiya W Nakamura M A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study
description	Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto NakamuraDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, JapanBackground: Leber hereditary optic neuropathy (LHON) is a maternally inherited disease caused by three missense mutations of mitochondrial (mt) DNA, ie, m 3460 G>A, m 11778 G>A, or m 14484 T>C in the greater portion of LHON. m 11778 G>A mutation is especially observed in >90% of the cases in Japanese families. Although spontaneous remission of visual function infrequently occurs, effective treatment for LHON remains unestablished. Transcorneal electrical stimulation has been shown to be efficacious in individuals with optic neuropathy. However, due to potential risk of corneal damage, repeated treatments are not permissible. In this exploratory study, we will be conducting skin electrical stimulation (SES) as an intervention for patients with LHON having 11778 missense mutation and investigate effectiveness and safety of SES.Methods: This is a single-arm, prospective, open-label exploratory trial focused on patients with LHON having 11778 missense mutation. Eleven patients will be enrolled and receive six consecutive SES once every 2 weeks up to 10 weeks. The safety of the SES will be monitored with specular microscopy, slit-lamp biomicroscopy, fundus examinations, and the observation of facial skin. The primary outcome measure will be the averaged l ogarithm of minimum angle resolution (logMAR) converted visual acuity 1 week after the last SES. Secondary outcome measures include changes, in logMAR at 4 and 8 weeks after the last SES, such as visual field indices measured using Humphrey visual field and microperimetry-3, the thickness of peripapillary retinal fiber and macular ganglion cell complex, multifocal visual evoked potentials, critical flicker frequency, and color vision.Discussion: The results of this proposed proof-of-concept feasibility trial will help plan and execute a larger definitive trial to test SES as an effective strategy for LHON and related optic neuropathies and help establish a beneficial treatment for LHON.Keywords: skin electrical stimulation, Leber hereditary optic neuropathy, logarithm of minimum angle resolution, single-arm study
format	article
author	Kurimoto T Ueda K Mori S Sakamoto M Yamada-Nakanishi Y Matsumiya W Nakamura M
author_facet	Kurimoto T Ueda K Mori S Sakamoto M Yamada-Nakanishi Y Matsumiya W Nakamura M
author_sort	Kurimoto T
title	A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study
title_short	A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study
title_full	A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study
title_fullStr	A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study
title_full_unstemmed	A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study
title_sort	study protocol for evaluating the efficacy and safety of skin electrical stimulation for leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/09daa241e5e442228fdede7d11e49841
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A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study

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