Role of osteogenic Dickkopf-1 in bone remodeling and bone healing in mice with type I diabetes mellitus

Abstract Type 1 diabetes mellitus (T1DM) is associated with low bone mass and a higher risk for fractures. Dickkopf-1 (Dkk1), which inhibits Wnt signaling, osteoblast function, and bone formation, has been found to be increased in the serum of patients with T1DM. Here, we investigated the functional...

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Autores principales: Nick Hildebrandt, Juliane Colditz, Caio Dutra, Paula Goes, Juliane Salbach-Hirsch, Sylvia Thiele, Lorenz C. Hofbauer, Martina Rauner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/09dd10169fcc433d81432c0755190613
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