Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

MCL1, a pro-survival BCL-2 related protein with rapid turnover rate, is often dysregulated in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its inhibition sensitises tumor cells to BH3 mimetic inhibitors.

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Autores principales:	Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di, Guanglei Zhuang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09dfe8475f7d4341b4c32047ce2e5387
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spelling	oai:doaj.org-article:09dfe8475f7d4341b4c32047ce2e53872021-12-02T15:34:01ZDeubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors10.1038/s41467-017-02693-92041-1723https://doaj.org/article/09dfe8475f7d4341b4c32047ce2e53872018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02693-9https://doaj.org/toc/2041-1723MCL1, a pro-survival BCL-2 related protein with rapid turnover rate, is often dysregulated in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its inhibition sensitises tumor cells to BH3 mimetic inhibitors.Shengzhe ZhangMeiying ZhangYing JingXia YinPengfei MaZhenfeng ZhangXiaojie WangWen DiGuanglei ZhuangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shengzhe Zhang Meiying Zhang Ying Jing Xia Yin Pengfei Ma Zhenfeng Zhang Xiaojie Wang Wen Di Guanglei Zhuang Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
description	MCL1, a pro-survival BCL-2 related protein with rapid turnover rate, is often dysregulated in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its inhibition sensitises tumor cells to BH3 mimetic inhibitors.
format	article
author	Shengzhe Zhang Meiying Zhang Ying Jing Xia Yin Pengfei Ma Zhenfeng Zhang Xiaojie Wang Wen Di Guanglei Zhuang
author_facet	Shengzhe Zhang Meiying Zhang Ying Jing Xia Yin Pengfei Ma Zhenfeng Zhang Xiaojie Wang Wen Di Guanglei Zhuang
author_sort	Shengzhe Zhang
title	Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
title_short	Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
title_full	Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
title_fullStr	Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
title_full_unstemmed	Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
title_sort	deubiquitinase usp13 dictates mcl1 stability and sensitivity to bh3 mimetic inhibitors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09dfe8475f7d4341b4c32047ce2e5387
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Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

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