Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

MCL1, a pro-survival BCL-2 related protein with rapid turnover rate, is often dysregulated in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its inhibition sensitises tumor cells to BH3 mimetic inhibitors.

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Autores principales: Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di, Guanglei Zhuang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/09dfe8475f7d4341b4c32047ce2e5387
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