Obesity and risk of colorectal cancer: a systematic review of prospective studies.

<h4>Background</h4>Mounting evidence indicates that obesity may be associated with the risk of colorectal cancer (CRC). To conduct a systematic review of prospective studies assessing the association of obesity with the risk of CRC using meta-analysis.<h4>Methodology/principal find...

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Autores principales:	Yanlei Ma, Yongzhi Yang, Feng Wang, Peng Zhang, Chenzhang Shi, Yang Zou, Huanlong Qin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09e610551a6845d09ce6bcaa3682064c
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spelling	oai:doaj.org-article:09e610551a6845d09ce6bcaa3682064c2021-11-18T08:01:05ZObesity and risk of colorectal cancer: a systematic review of prospective studies.1932-620310.1371/journal.pone.0053916https://doaj.org/article/09e610551a6845d09ce6bcaa3682064c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23349764/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Mounting evidence indicates that obesity may be associated with the risk of colorectal cancer (CRC). To conduct a systematic review of prospective studies assessing the association of obesity with the risk of CRC using meta-analysis.<h4>Methodology/principal findings</h4>Relevant studies were identified by a search of MEDLINE and EMBASE databases before January 2012, with no restrictions. We also reviewed reference lists from retrieved articles. We included prospective studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between general obesity [measured using body mass index (BMI)] or central obesity [measured using waist circumference (WC)] and the risk of colorectal, colon, or rectal cancer. Approximately 9, 000, 000 participants from several countries were included in this analysis. 41 studies on general obesity and 13 studies on central obesity were included in the meta-analysis. The pooled RRs of CRC for the obese vs. normal category of BMI were 1.334 (95% CI, 1.253-1.420), and the highest vs. lowest category of WC were 1.455 (95% CI, 1.327-1.596). There was heterogeneity among studies of BMI (P<0.001) but not among studies of WC (P=0.323).<h4>Conclusions</h4>Both of general and central obesity were positively associated with the risk of CRC in this meta-analysis.Yanlei MaYongzhi YangFeng WangPeng ZhangChenzhang ShiYang ZouHuanlong QinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53916 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanlei Ma Yongzhi Yang Feng Wang Peng Zhang Chenzhang Shi Yang Zou Huanlong Qin Obesity and risk of colorectal cancer: a systematic review of prospective studies.
description	<h4>Background</h4>Mounting evidence indicates that obesity may be associated with the risk of colorectal cancer (CRC). To conduct a systematic review of prospective studies assessing the association of obesity with the risk of CRC using meta-analysis.<h4>Methodology/principal findings</h4>Relevant studies were identified by a search of MEDLINE and EMBASE databases before January 2012, with no restrictions. We also reviewed reference lists from retrieved articles. We included prospective studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between general obesity [measured using body mass index (BMI)] or central obesity [measured using waist circumference (WC)] and the risk of colorectal, colon, or rectal cancer. Approximately 9, 000, 000 participants from several countries were included in this analysis. 41 studies on general obesity and 13 studies on central obesity were included in the meta-analysis. The pooled RRs of CRC for the obese vs. normal category of BMI were 1.334 (95% CI, 1.253-1.420), and the highest vs. lowest category of WC were 1.455 (95% CI, 1.327-1.596). There was heterogeneity among studies of BMI (P<0.001) but not among studies of WC (P=0.323).<h4>Conclusions</h4>Both of general and central obesity were positively associated with the risk of CRC in this meta-analysis.
format	article
author	Yanlei Ma Yongzhi Yang Feng Wang Peng Zhang Chenzhang Shi Yang Zou Huanlong Qin
author_facet	Yanlei Ma Yongzhi Yang Feng Wang Peng Zhang Chenzhang Shi Yang Zou Huanlong Qin
author_sort	Yanlei Ma
title	Obesity and risk of colorectal cancer: a systematic review of prospective studies.
title_short	Obesity and risk of colorectal cancer: a systematic review of prospective studies.
title_full	Obesity and risk of colorectal cancer: a systematic review of prospective studies.
title_fullStr	Obesity and risk of colorectal cancer: a systematic review of prospective studies.
title_full_unstemmed	Obesity and risk of colorectal cancer: a systematic review of prospective studies.
title_sort	obesity and risk of colorectal cancer: a systematic review of prospective studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/09e610551a6845d09ce6bcaa3682064c
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Obesity and risk of colorectal cancer: a systematic review of prospective studies.

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