Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations

Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.

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Autores principales: Yali Xue, Massimo Mezzavilla, Marc Haber, Shane McCarthy, Yuan Chen, Vagheesh Narasimhan, Arthur Gilly, Qasim Ayub, Vincenza Colonna, Lorraine Southam, Christopher Finan, Andrea Massaia, Himanshu Chheda, Priit Palta, Graham Ritchie, Jennifer Asimit, George Dedoussis, Paolo Gasparini, Aarno Palotie, Samuli Ripatti, Nicole Soranzo, Daniela Toniolo, James F. Wilson, Richard Durbin, Chris Tyler-Smith, Eleftheria Zeggini
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2
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spelling oai:doaj.org-article:09e63dea89244cb9bf890f07177b88d22021-12-02T14:42:20ZEnrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations10.1038/ncomms159272041-1723https://doaj.org/article/09e63dea89244cb9bf890f07177b88d22017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15927https://doaj.org/toc/2041-1723Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.Yali XueMassimo MezzavillaMarc HaberShane McCarthyYuan ChenVagheesh NarasimhanArthur GillyQasim AyubVincenza ColonnaLorraine SouthamChristopher FinanAndrea MassaiaHimanshu ChhedaPriit PaltaGraham RitchieJennifer AsimitGeorge DedoussisPaolo GaspariniAarno PalotieSamuli RipattiNicole SoranzoDaniela TonioloJames F. WilsonRichard DurbinChris Tyler-SmithEleftheria ZegginiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yali Xue
Massimo Mezzavilla
Marc Haber
Shane McCarthy
Yuan Chen
Vagheesh Narasimhan
Arthur Gilly
Qasim Ayub
Vincenza Colonna
Lorraine Southam
Christopher Finan
Andrea Massaia
Himanshu Chheda
Priit Palta
Graham Ritchie
Jennifer Asimit
George Dedoussis
Paolo Gasparini
Aarno Palotie
Samuli Ripatti
Nicole Soranzo
Daniela Toniolo
James F. Wilson
Richard Durbin
Chris Tyler-Smith
Eleftheria Zeggini
Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
description Isolated populations often have special genetic compositions that can be leveraged for genetic association studies. Here, Xue and colleagues generate and analyse 3,059 low-depth whole-genome sequences from eight European isolated populations and two matched general populations.
format article
author Yali Xue
Massimo Mezzavilla
Marc Haber
Shane McCarthy
Yuan Chen
Vagheesh Narasimhan
Arthur Gilly
Qasim Ayub
Vincenza Colonna
Lorraine Southam
Christopher Finan
Andrea Massaia
Himanshu Chheda
Priit Palta
Graham Ritchie
Jennifer Asimit
George Dedoussis
Paolo Gasparini
Aarno Palotie
Samuli Ripatti
Nicole Soranzo
Daniela Toniolo
James F. Wilson
Richard Durbin
Chris Tyler-Smith
Eleftheria Zeggini
author_facet Yali Xue
Massimo Mezzavilla
Marc Haber
Shane McCarthy
Yuan Chen
Vagheesh Narasimhan
Arthur Gilly
Qasim Ayub
Vincenza Colonna
Lorraine Southam
Christopher Finan
Andrea Massaia
Himanshu Chheda
Priit Palta
Graham Ritchie
Jennifer Asimit
George Dedoussis
Paolo Gasparini
Aarno Palotie
Samuli Ripatti
Nicole Soranzo
Daniela Toniolo
James F. Wilson
Richard Durbin
Chris Tyler-Smith
Eleftheria Zeggini
author_sort Yali Xue
title Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
title_short Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
title_full Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
title_fullStr Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
title_full_unstemmed Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
title_sort enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated european populations
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/09e63dea89244cb9bf890f07177b88d2
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