Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users

David J Browning,1 Chong Lee2 1Charlotte Eye, Ear, Nose and Throat Associates, 2University of North Carolina – Charlotte, Charlotte, NC, USA Purpose: To determine measurement variability of N1P1 amplitudes and the R1/R2 ratio in normal subjects and hydroxychloroquine users without retin...

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Autores principales:	Browning DJ, Lee C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/09e90a6126bd4aca97313e6b8ee6d0f2
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spelling	oai:doaj.org-article:09e90a6126bd4aca97313e6b8ee6d0f22021-12-02T02:14:11ZTest-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users1177-5483https://doaj.org/article/09e90a6126bd4aca97313e6b8ee6d0f22014-08-01T00:00:00Zhttp://www.dovepress.com/test-retest-variability-of-multifocal-electroretinography-in-normal-vo-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 David J Browning,1 Chong Lee2 1Charlotte Eye, Ear, Nose and Throat Associates, 2University of North Carolina – Charlotte, Charlotte, NC, USA Purpose: To determine measurement variability of N1P1 amplitudes and the R1/R2 ratio in normal subjects and hydroxychloroquine users without retinopathy. Design: Retrospective, observational study. Subjects: Normal subjects (n=21) and 44 patients taking hydroxychloroquine (n=44) without retinopathy. Methods: Multifocal electroretinography (mfERG) was performed twice in one session in the 21 normal subjects and twice within 1 year in the hydroxychloroquine users, during which time no clinical change in macular status occurred. Main outcome measures: N1P1 amplitudes of rings R1–R5, the R1/R2 ratio, and coefficients of repeatability (COR) for these measurements. Results: Values for N1P1 amplitudes in hydroxychloroquine users were reduced compared with normal subjects by the known effect of age, but R1/R2 was not affected by age. The COR for R1–R5 ranged from 43% to 52% for normal subjects and from 43% to 59% for hydroxychloroquine users; for R1/R2 the COR was 29% in normal subjects and 45% in hydroxychloroquine users. Conclusion: mfERG measurements show high test-retest variability, limiting the ability of a single mfERG test to influence a decision to stop hydroxychloroquine; corroborative evidence with a different ancillary test is recommended in a suspicious case. Keywords: multifocal electroretinography, hydroxychloroquine, test-retest variability Browning DJLee CDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1467-1473 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Browning DJ Lee C Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
description	David J Browning,1 Chong Lee2 1Charlotte Eye, Ear, Nose and Throat Associates, 2University of North Carolina – Charlotte, Charlotte, NC, USA Purpose: To determine measurement variability of N1P1 amplitudes and the R1/R2 ratio in normal subjects and hydroxychloroquine users without retinopathy. Design: Retrospective, observational study. Subjects: Normal subjects (n=21) and 44 patients taking hydroxychloroquine (n=44) without retinopathy. Methods: Multifocal electroretinography (mfERG) was performed twice in one session in the 21 normal subjects and twice within 1 year in the hydroxychloroquine users, during which time no clinical change in macular status occurred. Main outcome measures: N1P1 amplitudes of rings R1–R5, the R1/R2 ratio, and coefficients of repeatability (COR) for these measurements. Results: Values for N1P1 amplitudes in hydroxychloroquine users were reduced compared with normal subjects by the known effect of age, but R1/R2 was not affected by age. The COR for R1–R5 ranged from 43% to 52% for normal subjects and from 43% to 59% for hydroxychloroquine users; for R1/R2 the COR was 29% in normal subjects and 45% in hydroxychloroquine users. Conclusion: mfERG measurements show high test-retest variability, limiting the ability of a single mfERG test to influence a decision to stop hydroxychloroquine; corroborative evidence with a different ancillary test is recommended in a suspicious case. Keywords: multifocal electroretinography, hydroxychloroquine, test-retest variability
format	article
author	Browning DJ Lee C
author_facet	Browning DJ Lee C
author_sort	Browning DJ
title	Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
title_short	Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
title_full	Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
title_fullStr	Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
title_full_unstemmed	Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
title_sort	test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/09e90a6126bd4aca97313e6b8ee6d0f2
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Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users

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