Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology

Progranulin (PGRN) mutations cause frontotemporal lobe dementia with TDP-43 pathology. Here the authors develop a mutant PGRN knock-in mouse model of the disease, and show that Tyro3, a tyrosine kinase membrane receptor that acts upstream of PKC and MAPK, is inhibited by PGRN which contributes to pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano, Hitoshi Okazawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09ed0cd6cc5041bf8759b3550eb3f80b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:09ed0cd6cc5041bf8759b3550eb3f80b
record_format	dspace
spelling	oai:doaj.org-article:09ed0cd6cc5041bf8759b3550eb3f80b2021-12-02T14:39:23ZTargeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology10.1038/s41467-018-02821-z2041-1723https://doaj.org/article/09ed0cd6cc5041bf8759b3550eb3f80b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02821-zhttps://doaj.org/toc/2041-1723Progranulin (PGRN) mutations cause frontotemporal lobe dementia with TDP-43 pathology. Here the authors develop a mutant PGRN knock-in mouse model of the disease, and show that Tyro3, a tyrosine kinase membrane receptor that acts upstream of PKC and MAPK, is inhibited by PGRN which contributes to pathology in this model.Kyota FujitaXigui ChenHidenori HommaKazuhiko TagawaMutsuki AmanoAyumu SaitoSeiya ImotoHiroyasu AkatsuYoshio HashizumeKozo KaibuchiSatoru MiyanoHitoshi OkazawaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyota Fujita Xigui Chen Hidenori Homma Kazuhiko Tagawa Mutsuki Amano Ayumu Saito Seiya Imoto Hiroyasu Akatsu Yoshio Hashizume Kozo Kaibuchi Satoru Miyano Hitoshi Okazawa Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
description	Progranulin (PGRN) mutations cause frontotemporal lobe dementia with TDP-43 pathology. Here the authors develop a mutant PGRN knock-in mouse model of the disease, and show that Tyro3, a tyrosine kinase membrane receptor that acts upstream of PKC and MAPK, is inhibited by PGRN which contributes to pathology in this model.
format	article
author	Kyota Fujita Xigui Chen Hidenori Homma Kazuhiko Tagawa Mutsuki Amano Ayumu Saito Seiya Imoto Hiroyasu Akatsu Yoshio Hashizume Kozo Kaibuchi Satoru Miyano Hitoshi Okazawa
author_facet	Kyota Fujita Xigui Chen Hidenori Homma Kazuhiko Tagawa Mutsuki Amano Ayumu Saito Seiya Imoto Hiroyasu Akatsu Yoshio Hashizume Kozo Kaibuchi Satoru Miyano Hitoshi Okazawa
author_sort	Kyota Fujita
title	Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
title_short	Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
title_full	Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
title_fullStr	Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
title_full_unstemmed	Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
title_sort	targeting tyro3 ameliorates a model of pgrn-mutant ftld-tdp via tau-mediated synaptic pathology
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09ed0cd6cc5041bf8759b3550eb3f80b
work_keys_str_mv	AT kyotafujita targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT xiguichen targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT hidenorihomma targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT kazuhikotagawa targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT mutsukiamano targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT ayumusaito targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT seiyaimoto targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT hiroyasuakatsu targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT yoshiohashizume targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT kozokaibuchi targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT satorumiyano targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology AT hitoshiokazawa targetingtyro3amelioratesamodelofpgrnmutantftldtdpviataumediatedsynapticpathology
_version_	1718390636654100480

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology

Ejemplares similares