Neutrophils Orchestrate the Periodontal Pocket

The subgingival biofilm attached to tooth surfaces triggers and maintains periodontitis. Previously, late-onset periodontitis has been considered a consequence of dysbiosis and a resultant polymicrobial disruption of host homeostasis. However, a multitude of studies did not show “healthy” oral micro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ljubomir Vitkov, Luis E. Muñoz, Janina Schoen, Jasmin Knopf, Christine Schauer, Bernd Minnich, Martin Herrmann, Matthias Hannig
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dysbiosis dysregulated immunity NET formation caspase 4 caspase 11 bacterial membrane vesicles Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/09f6f2d40de245ad84d0c676a891723a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:09f6f2d40de245ad84d0c676a891723a
record_format	dspace
spelling	oai:doaj.org-article:09f6f2d40de245ad84d0c676a891723a2021-11-30T19:11:00ZNeutrophils Orchestrate the Periodontal Pocket1664-322410.3389/fimmu.2021.788766https://doaj.org/article/09f6f2d40de245ad84d0c676a891723a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.788766/fullhttps://doaj.org/toc/1664-3224The subgingival biofilm attached to tooth surfaces triggers and maintains periodontitis. Previously, late-onset periodontitis has been considered a consequence of dysbiosis and a resultant polymicrobial disruption of host homeostasis. However, a multitude of studies did not show “healthy” oral microbiota pattern, but a high diversity depending on culture, diets, regional differences, age, social state etc. These findings relativise the aetiological role of the dysbiosis in periodontitis. Furthermore, many late-onset periodontitis traits cannot be explained by dysbiosis; e.g. age-relatedness, attenuation by anti-ageing therapy, neutrophil hyper-responsiveness, and microbiota shifting by dysregulated immunity, yet point to the crucial role of dysregulated immunity and neutrophils in particular. Furthermore, patients with neutropenia and neutrophil defects inevitably develop early-onset periodontitis. Intra-gingivally injecting lipopolysaccharide (LPS) alone causes an exaggerated neutrophil response sufficient to precipitate experimental periodontitis. Vice versa to the surplus of LPS, the increased neutrophil responsiveness characteristic for late-onset periodontitis can effectuate gingiva damage likewise. The exaggerated neutrophil extracellular trap (NET) response in late-onset periodontitis is blameable for damage of gingival barrier, its penetration by bacteria and pathogen-associated molecular patterns (PAMPs) as well as stimulation of Th17 cells, resulting in further neutrophil activation. This identifies the dysregulated immunity as the main contributor to periodontal disease.Ljubomir VitkovLjubomir VitkovLuis E. MuñozLuis E. MuñozJanina SchoenJanina SchoenJasmin KnopfJasmin KnopfChristine SchauerChristine SchauerBernd MinnichMartin HerrmannMartin HerrmannMatthias HannigFrontiers Media S.A.articledysbiosisdysregulated immunityNET formationcaspase 4caspase 11bacterial membrane vesiclesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dysbiosis dysregulated immunity NET formation caspase 4 caspase 11 bacterial membrane vesicles Immunologic diseases. Allergy RC581-607
spellingShingle	dysbiosis dysregulated immunity NET formation caspase 4 caspase 11 bacterial membrane vesicles Immunologic diseases. Allergy RC581-607 Ljubomir Vitkov Ljubomir Vitkov Luis E. Muñoz Luis E. Muñoz Janina Schoen Janina Schoen Jasmin Knopf Jasmin Knopf Christine Schauer Christine Schauer Bernd Minnich Martin Herrmann Martin Herrmann Matthias Hannig Neutrophils Orchestrate the Periodontal Pocket
description	The subgingival biofilm attached to tooth surfaces triggers and maintains periodontitis. Previously, late-onset periodontitis has been considered a consequence of dysbiosis and a resultant polymicrobial disruption of host homeostasis. However, a multitude of studies did not show “healthy” oral microbiota pattern, but a high diversity depending on culture, diets, regional differences, age, social state etc. These findings relativise the aetiological role of the dysbiosis in periodontitis. Furthermore, many late-onset periodontitis traits cannot be explained by dysbiosis; e.g. age-relatedness, attenuation by anti-ageing therapy, neutrophil hyper-responsiveness, and microbiota shifting by dysregulated immunity, yet point to the crucial role of dysregulated immunity and neutrophils in particular. Furthermore, patients with neutropenia and neutrophil defects inevitably develop early-onset periodontitis. Intra-gingivally injecting lipopolysaccharide (LPS) alone causes an exaggerated neutrophil response sufficient to precipitate experimental periodontitis. Vice versa to the surplus of LPS, the increased neutrophil responsiveness characteristic for late-onset periodontitis can effectuate gingiva damage likewise. The exaggerated neutrophil extracellular trap (NET) response in late-onset periodontitis is blameable for damage of gingival barrier, its penetration by bacteria and pathogen-associated molecular patterns (PAMPs) as well as stimulation of Th17 cells, resulting in further neutrophil activation. This identifies the dysregulated immunity as the main contributor to periodontal disease.
format	article
author	Ljubomir Vitkov Ljubomir Vitkov Luis E. Muñoz Luis E. Muñoz Janina Schoen Janina Schoen Jasmin Knopf Jasmin Knopf Christine Schauer Christine Schauer Bernd Minnich Martin Herrmann Martin Herrmann Matthias Hannig
author_facet	Ljubomir Vitkov Ljubomir Vitkov Luis E. Muñoz Luis E. Muñoz Janina Schoen Janina Schoen Jasmin Knopf Jasmin Knopf Christine Schauer Christine Schauer Bernd Minnich Martin Herrmann Martin Herrmann Matthias Hannig
author_sort	Ljubomir Vitkov
title	Neutrophils Orchestrate the Periodontal Pocket
title_short	Neutrophils Orchestrate the Periodontal Pocket
title_full	Neutrophils Orchestrate the Periodontal Pocket
title_fullStr	Neutrophils Orchestrate the Periodontal Pocket
title_full_unstemmed	Neutrophils Orchestrate the Periodontal Pocket
title_sort	neutrophils orchestrate the periodontal pocket
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/09f6f2d40de245ad84d0c676a891723a
work_keys_str_mv	AT ljubomirvitkov neutrophilsorchestratetheperiodontalpocket AT ljubomirvitkov neutrophilsorchestratetheperiodontalpocket AT luisemunoz neutrophilsorchestratetheperiodontalpocket AT luisemunoz neutrophilsorchestratetheperiodontalpocket AT janinaschoen neutrophilsorchestratetheperiodontalpocket AT janinaschoen neutrophilsorchestratetheperiodontalpocket AT jasminknopf neutrophilsorchestratetheperiodontalpocket AT jasminknopf neutrophilsorchestratetheperiodontalpocket AT christineschauer neutrophilsorchestratetheperiodontalpocket AT christineschauer neutrophilsorchestratetheperiodontalpocket AT berndminnich neutrophilsorchestratetheperiodontalpocket AT martinherrmann neutrophilsorchestratetheperiodontalpocket AT martinherrmann neutrophilsorchestratetheperiodontalpocket AT matthiashannig neutrophilsorchestratetheperiodontalpocket
_version_	1718406303881101312

Neutrophils Orchestrate the Periodontal Pocket

Ejemplares similares