Tissue-resident memory T cells populate the human brain

Tissue-resident immune cells are important for local protections from pathogens. Here the authors show that brain tissue-resident memory T cells (TRM cells) can be further subsetted by CD103 expression, with higher CD103 correlates with increased chemokine receptor and exhaustion markers such as PD1...

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Autores principales:	Joost Smolders, Kirstin M. Heutinck, Nina L. Fransen, Ester B. M. Remmerswaal, Pleun Hombrink, Ineke J. M. ten Berge, René A. W. van Lier, Inge Huitinga, Jörg Hamann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/09f88e2c0be147e490b9a971399626e0
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spelling	oai:doaj.org-article:09f88e2c0be147e490b9a971399626e02021-12-02T16:49:32ZTissue-resident memory T cells populate the human brain10.1038/s41467-018-07053-92041-1723https://doaj.org/article/09f88e2c0be147e490b9a971399626e02018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07053-9https://doaj.org/toc/2041-1723Tissue-resident immune cells are important for local protections from pathogens. Here the authors show that brain tissue-resident memory T cells (TRM cells) can be further subsetted by CD103 expression, with higher CD103 correlates with increased chemokine receptor and exhaustion markers such as PD1 or CTLA4, but reduced differentiation markers.Joost SmoldersKirstin M. HeutinckNina L. FransenEster B. M. RemmerswaalPleun HombrinkIneke J. M. ten BergeRené A. W. van LierInge HuitingaJörg HamannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joost Smolders Kirstin M. Heutinck Nina L. Fransen Ester B. M. Remmerswaal Pleun Hombrink Ineke J. M. ten Berge René A. W. van Lier Inge Huitinga Jörg Hamann Tissue-resident memory T cells populate the human brain
description	Tissue-resident immune cells are important for local protections from pathogens. Here the authors show that brain tissue-resident memory T cells (TRM cells) can be further subsetted by CD103 expression, with higher CD103 correlates with increased chemokine receptor and exhaustion markers such as PD1 or CTLA4, but reduced differentiation markers.
format	article
author	Joost Smolders Kirstin M. Heutinck Nina L. Fransen Ester B. M. Remmerswaal Pleun Hombrink Ineke J. M. ten Berge René A. W. van Lier Inge Huitinga Jörg Hamann
author_facet	Joost Smolders Kirstin M. Heutinck Nina L. Fransen Ester B. M. Remmerswaal Pleun Hombrink Ineke J. M. ten Berge René A. W. van Lier Inge Huitinga Jörg Hamann
author_sort	Joost Smolders
title	Tissue-resident memory T cells populate the human brain
title_short	Tissue-resident memory T cells populate the human brain
title_full	Tissue-resident memory T cells populate the human brain
title_fullStr	Tissue-resident memory T cells populate the human brain
title_full_unstemmed	Tissue-resident memory T cells populate the human brain
title_sort	tissue-resident memory t cells populate the human brain
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09f88e2c0be147e490b9a971399626e0
work_keys_str_mv	AT joostsmolders tissueresidentmemorytcellspopulatethehumanbrain AT kirstinmheutinck tissueresidentmemorytcellspopulatethehumanbrain AT ninalfransen tissueresidentmemorytcellspopulatethehumanbrain AT esterbmremmerswaal tissueresidentmemorytcellspopulatethehumanbrain AT pleunhombrink tissueresidentmemorytcellspopulatethehumanbrain AT inekejmtenberge tissueresidentmemorytcellspopulatethehumanbrain AT reneawvanlier tissueresidentmemorytcellspopulatethehumanbrain AT ingehuitinga tissueresidentmemorytcellspopulatethehumanbrain AT jorghamann tissueresidentmemorytcellspopulatethehumanbrain
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Tissue-resident memory T cells populate the human brain

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