Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection

Since the start of the COVID-19 pandemic, there have been multiple reports of related thyroid dysfunction, most commonly, thyroiditis. The exact mechanism for this has not been elucidated, but it is known that thyroid gland cells have both angiotensin-converting enzyme 2 (ACE2) and transmembrane pro...

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Autores principales:	Khary Edwards MD, Iram Hussain MD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920 Pathology RB1-214
Acceso en línea:	https://doaj.org/article/09f9ca5cac5442b79ff78168acd9c62f
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spelling	oai:doaj.org-article:09f9ca5cac5442b79ff78168acd9c62f2021-12-01T02:04:05ZTwo Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection2324-709610.1177/23247096211056497https://doaj.org/article/09f9ca5cac5442b79ff78168acd9c62f2021-11-01T00:00:00Zhttps://doi.org/10.1177/23247096211056497https://doaj.org/toc/2324-7096Since the start of the COVID-19 pandemic, there have been multiple reports of related thyroid dysfunction, most commonly, thyroiditis. The exact mechanism for this has not been elucidated, but it is known that thyroid gland cells have both angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) receptors, which the SARS-CoV-2 virus uses to enter cells. While SARS-CoV-2 has also been shown to precipitate other autoimmune diseases, there are only a few reported cases of new onset Graves’ disease in the setting of SARS-CoV-2 infection. We report 2 patients who presented with severe thyrotoxicosis (thyroid storm and impending storm) that was likely precipitated by SARS-CoV-2 infection. Both patients had no previous history of hyperthyroidism, and potentially also developed Graves’ disease after getting COVID-19. The addition of these cases to the medical literature will further highlight the fact that SARS-CoV-2 infection should be considered a causative agent for thyrotoxicosis when no other cause can be found, and that SARS-CoV-2 may be a potential trigger for autoimmune thyroid disease. It is important to know the SARS-CoV-2 status of such patients for infection control purposes, and to identify patients who may have their hospital course complicated by this disease. These cases may also help further our understanding of the etiology of autoimmune thyroid disease following a viral infection.Khary Edwards MDIram Hussain MDSAGE PublishingarticleMedicine (General)R5-920PathologyRB1-214ENJournal of Investigative Medicine High Impact Case Reports, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Pathology RB1-214
spellingShingle	Medicine (General) R5-920 Pathology RB1-214 Khary Edwards MD Iram Hussain MD Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection
description	Since the start of the COVID-19 pandemic, there have been multiple reports of related thyroid dysfunction, most commonly, thyroiditis. The exact mechanism for this has not been elucidated, but it is known that thyroid gland cells have both angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) receptors, which the SARS-CoV-2 virus uses to enter cells. While SARS-CoV-2 has also been shown to precipitate other autoimmune diseases, there are only a few reported cases of new onset Graves’ disease in the setting of SARS-CoV-2 infection. We report 2 patients who presented with severe thyrotoxicosis (thyroid storm and impending storm) that was likely precipitated by SARS-CoV-2 infection. Both patients had no previous history of hyperthyroidism, and potentially also developed Graves’ disease after getting COVID-19. The addition of these cases to the medical literature will further highlight the fact that SARS-CoV-2 infection should be considered a causative agent for thyrotoxicosis when no other cause can be found, and that SARS-CoV-2 may be a potential trigger for autoimmune thyroid disease. It is important to know the SARS-CoV-2 status of such patients for infection control purposes, and to identify patients who may have their hospital course complicated by this disease. These cases may also help further our understanding of the etiology of autoimmune thyroid disease following a viral infection.
format	article
author	Khary Edwards MD Iram Hussain MD
author_facet	Khary Edwards MD Iram Hussain MD
author_sort	Khary Edwards MD
title	Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection
title_short	Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection
title_full	Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection
title_fullStr	Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection
title_full_unstemmed	Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection
title_sort	two cases of severe autoimmune thyrotoxicosis following sars-cov-2 infection
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/09f9ca5cac5442b79ff78168acd9c62f
work_keys_str_mv	AT kharyedwardsmd twocasesofsevereautoimmunethyrotoxicosisfollowingsarscov2infection AT iramhussainmd twocasesofsevereautoimmunethyrotoxicosisfollowingsarscov2infection
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Two Cases of Severe Autoimmune Thyrotoxicosis Following SARS-CoV-2 Infection

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