Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart

How coronary vessels develop and respond to injury is not fully understood. Here, the authors use murine enhancer:reporter models to identify three transcriptional pathways active in different parts of coronary vasculature. These also contribute to neovascularization in the injured neonatal, but not...

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Autores principales: Sophie Payne, Mala Gunadasa-Rohling, Alice Neal, Andia N. Redpath, Jyoti Patel, Kira M. Chouliaras, Indrika Ratnayaka, Nicola Smart, Sarah De Val
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/09fd5481e99346098921b08317905204
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spelling oai:doaj.org-article:09fd5481e99346098921b083179052042021-12-02T16:58:29ZRegulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart10.1038/s41467-019-10710-22041-1723https://doaj.org/article/09fd5481e99346098921b083179052042019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10710-2https://doaj.org/toc/2041-1723How coronary vessels develop and respond to injury is not fully understood. Here, the authors use murine enhancer:reporter models to identify three transcriptional pathways active in different parts of coronary vasculature. These also contribute to neovascularization in the injured neonatal, but not adult, heart.Sophie PayneMala Gunadasa-RohlingAlice NealAndia N. RedpathJyoti PatelKira M. ChouliarasIndrika RatnayakaNicola SmartSarah De ValNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sophie Payne
Mala Gunadasa-Rohling
Alice Neal
Andia N. Redpath
Jyoti Patel
Kira M. Chouliaras
Indrika Ratnayaka
Nicola Smart
Sarah De Val
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
description How coronary vessels develop and respond to injury is not fully understood. Here, the authors use murine enhancer:reporter models to identify three transcriptional pathways active in different parts of coronary vasculature. These also contribute to neovascularization in the injured neonatal, but not adult, heart.
format article
author Sophie Payne
Mala Gunadasa-Rohling
Alice Neal
Andia N. Redpath
Jyoti Patel
Kira M. Chouliaras
Indrika Ratnayaka
Nicola Smart
Sarah De Val
author_facet Sophie Payne
Mala Gunadasa-Rohling
Alice Neal
Andia N. Redpath
Jyoti Patel
Kira M. Chouliaras
Indrika Ratnayaka
Nicola Smart
Sarah De Val
author_sort Sophie Payne
title Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
title_short Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
title_full Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
title_fullStr Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
title_full_unstemmed Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
title_sort regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/09fd5481e99346098921b08317905204
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