Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart
How coronary vessels develop and respond to injury is not fully understood. Here, the authors use murine enhancer:reporter models to identify three transcriptional pathways active in different parts of coronary vasculature. These also contribute to neovascularization in the injured neonatal, but not...
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Nature Portfolio
2019
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oai:doaj.org-article:09fd5481e99346098921b083179052042021-12-02T16:58:29ZRegulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart10.1038/s41467-019-10710-22041-1723https://doaj.org/article/09fd5481e99346098921b083179052042019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10710-2https://doaj.org/toc/2041-1723How coronary vessels develop and respond to injury is not fully understood. Here, the authors use murine enhancer:reporter models to identify three transcriptional pathways active in different parts of coronary vasculature. These also contribute to neovascularization in the injured neonatal, but not adult, heart.Sophie PayneMala Gunadasa-RohlingAlice NealAndia N. RedpathJyoti PatelKira M. ChouliarasIndrika RatnayakaNicola SmartSarah De ValNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
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Science Q Sophie Payne Mala Gunadasa-Rohling Alice Neal Andia N. Redpath Jyoti Patel Kira M. Chouliaras Indrika Ratnayaka Nicola Smart Sarah De Val Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart |
description |
How coronary vessels develop and respond to injury is not fully understood. Here, the authors use murine enhancer:reporter models to identify three transcriptional pathways active in different parts of coronary vasculature. These also contribute to neovascularization in the injured neonatal, but not adult, heart. |
format |
article |
author |
Sophie Payne Mala Gunadasa-Rohling Alice Neal Andia N. Redpath Jyoti Patel Kira M. Chouliaras Indrika Ratnayaka Nicola Smart Sarah De Val |
author_facet |
Sophie Payne Mala Gunadasa-Rohling Alice Neal Andia N. Redpath Jyoti Patel Kira M. Chouliaras Indrika Ratnayaka Nicola Smart Sarah De Val |
author_sort |
Sophie Payne |
title |
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart |
title_short |
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart |
title_full |
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart |
title_fullStr |
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart |
title_full_unstemmed |
Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart |
title_sort |
regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/09fd5481e99346098921b08317905204 |
work_keys_str_mv |
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