Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions

Human induced pluripotent stem cells (hiPSCs) hold great promise for cardiovascular regeneration following ischemic injury. Considerable effort has been made toward the development and optimization of methods to differentiate hiPSCs into vascular cells, such as endothelial and smooth muscle cells (E...

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Autores principales:	Jee Eun Oh, Cholomi Jung, Young-sup Yoon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	human induced pluripotent stem cell endothelial cell smooth muscle cell stem cell cardiovascular disease regenerative medicine Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/09ffb386a6834076a432c3504635c24b
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spelling	oai:doaj.org-article:09ffb386a6834076a432c3504635c24b2021-11-25T18:00:21ZHuman Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions10.3390/jcdd81101482308-3425https://doaj.org/article/09ffb386a6834076a432c3504635c24b2021-11-01T00:00:00Zhttps://www.mdpi.com/2308-3425/8/11/148https://doaj.org/toc/2308-3425Human induced pluripotent stem cells (hiPSCs) hold great promise for cardiovascular regeneration following ischemic injury. Considerable effort has been made toward the development and optimization of methods to differentiate hiPSCs into vascular cells, such as endothelial and smooth muscle cells (ECs and SMCs). In particular, hiPSC-derived ECs have shown robust potential for promoting neovascularization in animal models of cardiovascular diseases, potentially achieving significant and sustained therapeutic benefits. However, the use of hiPSC-derived SMCs that possess high therapeutic relevance is a relatively new area of investigation, still in the earlier investigational stages. In this review, we first discuss different methodologies to derive vascular cells from hiPSCs with a particular emphasis on the role of key developmental signals. Furthermore, we propose a standardized framework for assessing and defining the EC and SMC identity that might be suitable for inducing tissue repair and regeneration. We then highlight the regenerative effects of hiPSC-derived vascular cells on animal models of myocardial infarction and hindlimb ischemia. Finally, we address several obstacles that need to be overcome to fully implement the use of hiPSC-derived vascular cells for clinical application.Jee Eun OhCholomi JungYoung-sup YoonMDPI AGarticlehuman induced pluripotent stem cellendothelial cellsmooth muscle cellstem cellcardiovascular diseaseregenerative medicineDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Development and Disease, Vol 8, Iss 148, p 148 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human induced pluripotent stem cell endothelial cell smooth muscle cell stem cell cardiovascular disease regenerative medicine Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	human induced pluripotent stem cell endothelial cell smooth muscle cell stem cell cardiovascular disease regenerative medicine Diseases of the circulatory (Cardiovascular) system RC666-701 Jee Eun Oh Cholomi Jung Young-sup Yoon Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions
description	Human induced pluripotent stem cells (hiPSCs) hold great promise for cardiovascular regeneration following ischemic injury. Considerable effort has been made toward the development and optimization of methods to differentiate hiPSCs into vascular cells, such as endothelial and smooth muscle cells (ECs and SMCs). In particular, hiPSC-derived ECs have shown robust potential for promoting neovascularization in animal models of cardiovascular diseases, potentially achieving significant and sustained therapeutic benefits. However, the use of hiPSC-derived SMCs that possess high therapeutic relevance is a relatively new area of investigation, still in the earlier investigational stages. In this review, we first discuss different methodologies to derive vascular cells from hiPSCs with a particular emphasis on the role of key developmental signals. Furthermore, we propose a standardized framework for assessing and defining the EC and SMC identity that might be suitable for inducing tissue repair and regeneration. We then highlight the regenerative effects of hiPSC-derived vascular cells on animal models of myocardial infarction and hindlimb ischemia. Finally, we address several obstacles that need to be overcome to fully implement the use of hiPSC-derived vascular cells for clinical application.
format	article
author	Jee Eun Oh Cholomi Jung Young-sup Yoon
author_facet	Jee Eun Oh Cholomi Jung Young-sup Yoon
author_sort	Jee Eun Oh
title	Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions
title_short	Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions
title_full	Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions
title_fullStr	Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions
title_full_unstemmed	Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions
title_sort	human induced pluripotent stem cell-derived vascular cells: recent progress and future directions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/09ffb386a6834076a432c3504635c24b
work_keys_str_mv	AT jeeeunoh humaninducedpluripotentstemcellderivedvascularcellsrecentprogressandfuturedirections AT cholomijung humaninducedpluripotentstemcellderivedvascularcellsrecentprogressandfuturedirections AT youngsupyoon humaninducedpluripotentstemcellderivedvascularcellsrecentprogressandfuturedirections
_version_	1718411722998415360

Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions

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