Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis

Introduction: Predictive biomarkers for the therapeutic outcome of induction therapy with systemic corticosteroid for active ulcerative colitis (UC) have not been established. This study aimed to investigate whether neutrophil-to-lymphocyte ratio (NLR) and/or platelet-to-lymphocyte ratio (PLR) can b...

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Autores principales:	Katsuya Endo, Tomonori Satoh, Yuki Yoshino, Shiho Kondo, Yoko Kawakami, Tomofumi Katayama, Yoshiteru Sasaki, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Takayoshi Meguro, Kennichi Satoh
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	ulcerative colitis corticosteroid neutrophil/lymphocyte ratio platelet/lymphocyte ratio Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/0a0124e7a6ef4c5c93cd987316a6ee45
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spelling	oai:doaj.org-article:0a0124e7a6ef4c5c93cd987316a6ee452021-12-02T12:40:23ZNeutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis2296-94032296-936510.1159/000520523https://doaj.org/article/0a0124e7a6ef4c5c93cd987316a6ee452021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520523https://doaj.org/toc/2296-9403https://doaj.org/toc/2296-9365Introduction: Predictive biomarkers for the therapeutic outcome of induction therapy with systemic corticosteroid for active ulcerative colitis (UC) have not been established. This study aimed to investigate whether neutrophil-to-lymphocyte ratio (NLR) and/or platelet-to-lymphocyte ratio (PLR) can be predictive biomarkers for the therapeutic outcomes of systemic corticosteroid therapy in UC. Methods: This was a single-center retrospective cohort study. In total, 48 patients with UC who received induction therapy with systemic corticosteroid were enrolled. Based on the achievement of clinical remission after 8 weeks of treatment, the patients were divided into the remission group (n = 28) and the nonremission group (n = 20). Clinical characteristics, NLR, and PLR at baseline between the remission and nonremission groups were compared via a univariate analysis. The independent risk factors of nonremission were identified via a multivariate analysis. Results: The baseline Mayo score, platelet count, lymphocyte count, C-reactive protein (CRP) levels, NLR, and PLR between the 2 groups significantly differed. The nonremission group had higher NLR and PLR than the remission group (4.70 [3.04–11.3] vs. 3.10 [1.36–16.42]; p < 0.05, and 353.6 [220.3–499.8] vs. 207.2 [174.4–243.6]; p < 0.001, respectively). A multivariate analysis revealed that a Mayo score of ≥9, CRP level of ≥1.26 mg/dL, and PLR of ≥262 (hazard ratio: 23.1, 95% confidence interval: 1.29–413.7, p = 0.033) were considered independent risk factors for nonremission. Conclusion: This report first identified the efficacy of NLR and PLR as candidate biomarkers for predicting the therapeutic outcomes of systemic corticosteroid therapy in UC.Katsuya EndoTomonori SatohYuki YoshinoShiho KondoYoko KawakamiTomofumi KatayamaYoshiteru SasakiAtsuko TakasuTakayuki KogureMorihisa HirotaTakayoshi MeguroKennichi SatohKarger Publishersarticleulcerative colitiscorticosteroidneutrophil/lymphocyte ratioplatelet/lymphocyte ratioDiseases of the digestive system. GastroenterologyRC799-869ENInflammatory Intestinal Diseases, Vol 6, Iss 4, Pp 218-224 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ulcerative colitis corticosteroid neutrophil/lymphocyte ratio platelet/lymphocyte ratio Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	ulcerative colitis corticosteroid neutrophil/lymphocyte ratio platelet/lymphocyte ratio Diseases of the digestive system. Gastroenterology RC799-869 Katsuya Endo Tomonori Satoh Yuki Yoshino Shiho Kondo Yoko Kawakami Tomofumi Katayama Yoshiteru Sasaki Atsuko Takasu Takayuki Kogure Morihisa Hirota Takayoshi Meguro Kennichi Satoh Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis
description	Introduction: Predictive biomarkers for the therapeutic outcome of induction therapy with systemic corticosteroid for active ulcerative colitis (UC) have not been established. This study aimed to investigate whether neutrophil-to-lymphocyte ratio (NLR) and/or platelet-to-lymphocyte ratio (PLR) can be predictive biomarkers for the therapeutic outcomes of systemic corticosteroid therapy in UC. Methods: This was a single-center retrospective cohort study. In total, 48 patients with UC who received induction therapy with systemic corticosteroid were enrolled. Based on the achievement of clinical remission after 8 weeks of treatment, the patients were divided into the remission group (n = 28) and the nonremission group (n = 20). Clinical characteristics, NLR, and PLR at baseline between the remission and nonremission groups were compared via a univariate analysis. The independent risk factors of nonremission were identified via a multivariate analysis. Results: The baseline Mayo score, platelet count, lymphocyte count, C-reactive protein (CRP) levels, NLR, and PLR between the 2 groups significantly differed. The nonremission group had higher NLR and PLR than the remission group (4.70 [3.04–11.3] vs. 3.10 [1.36–16.42]; p < 0.05, and 353.6 [220.3–499.8] vs. 207.2 [174.4–243.6]; p < 0.001, respectively). A multivariate analysis revealed that a Mayo score of ≥9, CRP level of ≥1.26 mg/dL, and PLR of ≥262 (hazard ratio: 23.1, 95% confidence interval: 1.29–413.7, p = 0.033) were considered independent risk factors for nonremission. Conclusion: This report first identified the efficacy of NLR and PLR as candidate biomarkers for predicting the therapeutic outcomes of systemic corticosteroid therapy in UC.
format	article
author	Katsuya Endo Tomonori Satoh Yuki Yoshino Shiho Kondo Yoko Kawakami Tomofumi Katayama Yoshiteru Sasaki Atsuko Takasu Takayuki Kogure Morihisa Hirota Takayoshi Meguro Kennichi Satoh
author_facet	Katsuya Endo Tomonori Satoh Yuki Yoshino Shiho Kondo Yoko Kawakami Tomofumi Katayama Yoshiteru Sasaki Atsuko Takasu Takayuki Kogure Morihisa Hirota Takayoshi Meguro Kennichi Satoh
author_sort	Katsuya Endo
title	Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis
title_short	Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis
title_full	Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis
title_fullStr	Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis
title_full_unstemmed	Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis
title_sort	neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as noninvasive predictors of the therapeutic outcomes of systemic corticosteroid therapy in ulcerative colitis
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/0a0124e7a6ef4c5c93cd987316a6ee45
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Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Noninvasive Predictors of the Therapeutic Outcomes of Systemic Corticosteroid Therapy in Ulcerative Colitis

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