PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION

Decidual and placental macrophage pools are renewed due to its transendothelial monocyte migration from peripheral blood. Tissue macrophages control placental development and provide fetomaternal immunological tolerance. Preeclamptic pregnancy is accompanied by increased monocyte migration to decidu...

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Autores principales:	O. I. Stepanova, G. R. Kozonov, D. Z. Tsitskarava, T. U. Kuzminykh, D. A. Korenkov, S. A. Selkov, D. I. Sokolov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	placenta preeclampsia transendothelial migration thp-1 cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0a09f668e9e14b4ea16ad4a33ce81689
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spelling	oai:doaj.org-article:0a09f668e9e14b4ea16ad4a33ce816892021-11-18T08:03:37ZPLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION1563-06252313-741X10.15789/1563-0625-2013-2-131-140https://doaj.org/article/0a09f668e9e14b4ea16ad4a33ce816892014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/90https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDecidual and placental macrophage pools are renewed due to its transendothelial monocyte migration from peripheral blood. Tissue macrophages control placental development and provide fetomaternal immunological tolerance. Preeclamptic pregnancy is accompanied by increased monocyte migration to decidual tissue and local inflammatory events. Regulatory mechanisms of monocyte recruitment to placental and decidual tissues is still unclear. Therefore we investigated the influence soluble placental factors (SPFs) during the first- and third-trimester normal pregnancy, as compared to effects of these factors in preeclamptic pregnancy. We studied biological actions of SPF upon transendothelial migration of monocyte-like THP-1 cells and their phenotypic pattern. Transendothelial migration of THP-1 cells was more intensive with firsttrimester SPFs from normal pregnancy, when compared with third-trimester samples, and it was accompanied by decreased CD11a expression. SPFs from pre-eclamptic pregnancy caused an increase in transendothelial migration of THP-1 cells, as compared to SPFs from normal pregnancies, being accompanied by increased CD11b expression. The present study was supported by grants ГК № 02.740.11.0711, НШ-3594.2010.7, МД-150.2011.7 and a grant from St.-Petersburg Goverment for young scientists.O. I. StepanovaG. R. KozonovD. Z. TsitskaravaT. U. KuzminykhD. A. KorenkovS. A. SelkovD. I. SokolovSPb RAACIarticleplacentapreeclampsiatransendothelial migrationthp-1 cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 2, Pp 131-140 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	placenta preeclampsia transendothelial migration thp-1 cells Immunologic diseases. Allergy RC581-607
spellingShingle	placenta preeclampsia transendothelial migration thp-1 cells Immunologic diseases. Allergy RC581-607 O. I. Stepanova G. R. Kozonov D. Z. Tsitskarava T. U. Kuzminykh D. A. Korenkov S. A. Selkov D. I. Sokolov PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION
description	Decidual and placental macrophage pools are renewed due to its transendothelial monocyte migration from peripheral blood. Tissue macrophages control placental development and provide fetomaternal immunological tolerance. Preeclamptic pregnancy is accompanied by increased monocyte migration to decidual tissue and local inflammatory events. Regulatory mechanisms of monocyte recruitment to placental and decidual tissues is still unclear. Therefore we investigated the influence soluble placental factors (SPFs) during the first- and third-trimester normal pregnancy, as compared to effects of these factors in preeclamptic pregnancy. We studied biological actions of SPF upon transendothelial migration of monocyte-like THP-1 cells and their phenotypic pattern. Transendothelial migration of THP-1 cells was more intensive with firsttrimester SPFs from normal pregnancy, when compared with third-trimester samples, and it was accompanied by decreased CD11a expression. SPFs from pre-eclamptic pregnancy caused an increase in transendothelial migration of THP-1 cells, as compared to SPFs from normal pregnancies, being accompanied by increased CD11b expression. The present study was supported by grants ГК № 02.740.11.0711, НШ-3594.2010.7, МД-150.2011.7 and a grant from St.-Petersburg Goverment for young scientists.
format	article
author	O. I. Stepanova G. R. Kozonov D. Z. Tsitskarava T. U. Kuzminykh D. A. Korenkov S. A. Selkov D. I. Sokolov
author_facet	O. I. Stepanova G. R. Kozonov D. Z. Tsitskarava T. U. Kuzminykh D. A. Korenkov S. A. Selkov D. I. Sokolov
author_sort	O. I. Stepanova
title	PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION
title_short	PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION
title_full	PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION
title_fullStr	PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION
title_full_unstemmed	PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION
title_sort	placental secretory factors influence to thp-1 cells phenotype and thp-1 cells transendothelial migration
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/0a09f668e9e14b4ea16ad4a33ce81689
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PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION

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