Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level

Abstract Differentiated thyroid cancer (DTC) patients with negative serum thyroglobulin (Tg), negative 131I whole–body scintigraphy (131I-WBS) at first post-ablation and progressively increased TgAb level are a relatively rare entity in the follow-up after total thyroidectomy and radioactive iodine...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Zhong-Ling Qiu, Wei-Jun Wei, Chen-Tian Shen, Hong-Jun Song, Xin-Yun Zhang, Zhen-Kui Sun, Quan-Yong Luo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
R
Q
Acceso en línea:https://doaj.org/article/0a0b7d3f24874b7b90f6b6578ceb876f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0a0b7d3f24874b7b90f6b6578ceb876f
record_format dspace
spelling oai:doaj.org-article:0a0b7d3f24874b7b90f6b6578ceb876f2021-12-02T11:53:00ZDiagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level10.1038/s41598-017-03001-72045-2322https://doaj.org/article/0a0b7d3f24874b7b90f6b6578ceb876f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03001-7https://doaj.org/toc/2045-2322Abstract Differentiated thyroid cancer (DTC) patients with negative serum thyroglobulin (Tg), negative 131I whole–body scintigraphy (131I-WBS) at first post-ablation and progressively increased TgAb level are a relatively rare entity in the follow-up after total thyroidectomy and radioactive iodine therapy. The value of 18F-FDG PET/CT in detecting the recurrence of disease in these patients has only been reported in a small case series. The goal of this study was to investigate the diagnostic accuracy of 18F-FDG PET/CT in detecting recurrent disease in these specific PTC patients and to identify risk factors for patients with positive 18F-FDG PET/CT results. Eighty-two PTC patients who had 18F-FDG PET/CT scans with negative Tg, negative 131I-WBS at first post-ablation and progressively increased TgAb levels were included. We found that the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG PET/CT in this patient group were determined as 84%, 72%, 92%, 57% and 82%, respectively. 18F-FDG PET/CT scan had a good diagnostic performance and should be performed routinely in PTC patients with negative Tg, negative 131I-WBS at first postablation and progressively increased TgAb level, especially when span for progressively increased TgAb level ≥ 3 years and/or progressively increased TgAb value up to 150 IU/mL.Zhong-Ling QiuWei-Jun WeiChen-Tian ShenHong-Jun SongXin-Yun ZhangZhen-Kui SunQuan-Yong LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Zhong-Ling Qiu
Wei-Jun Wei
Chen-Tian Shen
Hong-Jun Song
Xin-Yun Zhang
Zhen-Kui Sun
Quan-Yong Luo
Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level
description Abstract Differentiated thyroid cancer (DTC) patients with negative serum thyroglobulin (Tg), negative 131I whole–body scintigraphy (131I-WBS) at first post-ablation and progressively increased TgAb level are a relatively rare entity in the follow-up after total thyroidectomy and radioactive iodine therapy. The value of 18F-FDG PET/CT in detecting the recurrence of disease in these patients has only been reported in a small case series. The goal of this study was to investigate the diagnostic accuracy of 18F-FDG PET/CT in detecting recurrent disease in these specific PTC patients and to identify risk factors for patients with positive 18F-FDG PET/CT results. Eighty-two PTC patients who had 18F-FDG PET/CT scans with negative Tg, negative 131I-WBS at first post-ablation and progressively increased TgAb levels were included. We found that the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG PET/CT in this patient group were determined as 84%, 72%, 92%, 57% and 82%, respectively. 18F-FDG PET/CT scan had a good diagnostic performance and should be performed routinely in PTC patients with negative Tg, negative 131I-WBS at first postablation and progressively increased TgAb level, especially when span for progressively increased TgAb level ≥ 3 years and/or progressively increased TgAb value up to 150 IU/mL.
format article
author Zhong-Ling Qiu
Wei-Jun Wei
Chen-Tian Shen
Hong-Jun Song
Xin-Yun Zhang
Zhen-Kui Sun
Quan-Yong Luo
author_facet Zhong-Ling Qiu
Wei-Jun Wei
Chen-Tian Shen
Hong-Jun Song
Xin-Yun Zhang
Zhen-Kui Sun
Quan-Yong Luo
author_sort Zhong-Ling Qiu
title Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level
title_short Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level
title_full Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level
title_fullStr Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level
title_full_unstemmed Diagnostic Performance of 18F-FDG PET/CT in Papillary Thyroid Carcinoma with Negative 131I-WBS at first Postablation, Negative Tg and Progressively Increased TgAb Level
title_sort diagnostic performance of 18f-fdg pet/ct in papillary thyroid carcinoma with negative 131i-wbs at first postablation, negative tg and progressively increased tgab level
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0a0b7d3f24874b7b90f6b6578ceb876f
work_keys_str_mv AT zhonglingqiu diagnosticperformanceof18ffdgpetctinpapillarythyroidcarcinomawithnegative131iwbsatfirstpostablationnegativetgandprogressivelyincreasedtgablevel
AT weijunwei diagnosticperformanceof18ffdgpetctinpapillarythyroidcarcinomawithnegative131iwbsatfirstpostablationnegativetgandprogressivelyincreasedtgablevel
AT chentianshen diagnosticperformanceof18ffdgpetctinpapillarythyroidcarcinomawithnegative131iwbsatfirstpostablationnegativetgandprogressivelyincreasedtgablevel
AT hongjunsong diagnosticperformanceof18ffdgpetctinpapillarythyroidcarcinomawithnegative131iwbsatfirstpostablationnegativetgandprogressivelyincreasedtgablevel
AT xinyunzhang diagnosticperformanceof18ffdgpetctinpapillarythyroidcarcinomawithnegative131iwbsatfirstpostablationnegativetgandprogressivelyincreasedtgablevel
AT zhenkuisun diagnosticperformanceof18ffdgpetctinpapillarythyroidcarcinomawithnegative131iwbsatfirstpostablationnegativetgandprogressivelyincreasedtgablevel
AT quanyongluo diagnosticperformanceof18ffdgpetctinpapillarythyroidcarcinomawithnegative131iwbsatfirstpostablationnegativetgandprogressivelyincreasedtgablevel
_version_ 1718394907085766656