Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

The transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in vivo and demonstrate that TOX expression contributes...

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Autores principales:	Nicolas Page, Sylvain Lemeille, Ilena Vincenti, Bogna Klimek, Alexandre Mariotte, Ingrid Wagner, Giovanni Di Liberto, Jonathan Kaye, Doron Merkler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a1022f34c2d437e8a387d622d23d03f
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spelling	oai:doaj.org-article:0a1022f34c2d437e8a387d622d23d03f2021-12-02T14:11:09ZPersistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling10.1038/s41467-021-21109-32041-1723https://doaj.org/article/0a1022f34c2d437e8a387d622d23d03f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21109-3https://doaj.org/toc/2041-1723The transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in vivo and demonstrate that TOX expression contributes to maintenance of auto-reactive CD8+ T cells through alteration of chromatin accessibility.Nicolas PageSylvain LemeilleIlena VincentiBogna KlimekAlexandre MariotteIngrid WagnerGiovanni Di LibertoJonathan KayeDoron MerklerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Page Sylvain Lemeille Ilena Vincenti Bogna Klimek Alexandre Mariotte Ingrid Wagner Giovanni Di Liberto Jonathan Kaye Doron Merkler Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
description	The transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in vivo and demonstrate that TOX expression contributes to maintenance of auto-reactive CD8+ T cells through alteration of chromatin accessibility.
format	article
author	Nicolas Page Sylvain Lemeille Ilena Vincenti Bogna Klimek Alexandre Mariotte Ingrid Wagner Giovanni Di Liberto Jonathan Kaye Doron Merkler
author_facet	Nicolas Page Sylvain Lemeille Ilena Vincenti Bogna Klimek Alexandre Mariotte Ingrid Wagner Giovanni Di Liberto Jonathan Kaye Doron Merkler
author_sort	Nicolas Page
title	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_short	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_full	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_fullStr	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_full_unstemmed	Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling
title_sort	persistence of self-reactive cd8+ t cells in the cns requires tox-dependent chromatin remodeling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a1022f34c2d437e8a387d622d23d03f
work_keys_str_mv	AT nicolaspage persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT sylvainlemeille persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT ilenavincenti persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT bognaklimek persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT alexandremariotte persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT ingridwagner persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT giovannidiliberto persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT jonathankaye persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling AT doronmerkler persistenceofselfreactivecd8tcellsinthecnsrequirestoxdependentchromatinremodeling
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Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling

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