Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles

Elastography is a noninvasive imaging technique that provides information on soft tissue stiffness. Young’s modulus is typically used to characterize soft tissues’ response to the applied force, as soft tissues are often considered linear elastic, isotropic, and quasi-incompressible materials. This...

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Autores principales:	E. Rizzuto, R. De Luca, A. Musarò, Z. Del Prete
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/0a1352e69699439e9e19d95c4f4e59d4
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spelling	oai:doaj.org-article:0a1352e69699439e9e19d95c4f4e59d42021-11-29T00:56:35ZMeasuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles2040-230910.1155/2021/5579232https://doaj.org/article/0a1352e69699439e9e19d95c4f4e59d42021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5579232https://doaj.org/toc/2040-2309Elastography is a noninvasive imaging technique that provides information on soft tissue stiffness. Young’s modulus is typically used to characterize soft tissues’ response to the applied force, as soft tissues are often considered linear elastic, isotropic, and quasi-incompressible materials. This approximation is reasonable for small strains, but soft tissues undergo large deformations also for small values of force and exhibit nonlinear elastic behavior. Outside the linear regime, the elastic modulus is dependent on the strain level and is different for any kind of tissue. The aim of this study was to characterize, ex vivo, the mechanical response of two different mice muscles to an external force. A system for transverse force-controlled uniaxial compression enabled obtaining the stress-strain (σ-ε) curve of the samples. The strain-dependent Young’s modulus (SYM) model was adopted to reproduce muscle compression behavior and to predict the elastic modulus for large deformations. After that, a recursive linear model was employed to identify the initial linear region of the σ-ε curve. Results showed that both muscle types exhibited a strain hardening effect and that the SYM model provided good fitting of the entire σ-ε curves. The application of the recursive linear model allowed capturing the initial linear region in which the approximation of these tissues as linear elastic materials is reasonable. The residual analysis displayed that even if the SYM model better summarizes the muscle behavior on the entire region, the linear model is more precise when considering only the initial part of the σ-ε curve.E. RizzutoR. De LucaA. MusaròZ. Del PreteHindawi LimitedarticleMedicine (General)R5-920Medical technologyR855-855.5ENJournal of Healthcare Engineering, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Medical technology R855-855.5
spellingShingle	Medicine (General) R5-920 Medical technology R855-855.5 E. Rizzuto R. De Luca A. Musarò Z. Del Prete Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles
description	Elastography is a noninvasive imaging technique that provides information on soft tissue stiffness. Young’s modulus is typically used to characterize soft tissues’ response to the applied force, as soft tissues are often considered linear elastic, isotropic, and quasi-incompressible materials. This approximation is reasonable for small strains, but soft tissues undergo large deformations also for small values of force and exhibit nonlinear elastic behavior. Outside the linear regime, the elastic modulus is dependent on the strain level and is different for any kind of tissue. The aim of this study was to characterize, ex vivo, the mechanical response of two different mice muscles to an external force. A system for transverse force-controlled uniaxial compression enabled obtaining the stress-strain (σ-ε) curve of the samples. The strain-dependent Young’s modulus (SYM) model was adopted to reproduce muscle compression behavior and to predict the elastic modulus for large deformations. After that, a recursive linear model was employed to identify the initial linear region of the σ-ε curve. Results showed that both muscle types exhibited a strain hardening effect and that the SYM model provided good fitting of the entire σ-ε curves. The application of the recursive linear model allowed capturing the initial linear region in which the approximation of these tissues as linear elastic materials is reasonable. The residual analysis displayed that even if the SYM model better summarizes the muscle behavior on the entire region, the linear model is more precise when considering only the initial part of the σ-ε curve.
format	article
author	E. Rizzuto R. De Luca A. Musarò Z. Del Prete
author_facet	E. Rizzuto R. De Luca A. Musarò Z. Del Prete
author_sort	E. Rizzuto
title	Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles
title_short	Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles
title_full	Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles
title_fullStr	Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles
title_full_unstemmed	Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles
title_sort	measuring and modelling nonlinear elasticity of ex vivo mouse muscles
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/0a1352e69699439e9e19d95c4f4e59d4
work_keys_str_mv	AT erizzuto measuringandmodellingnonlinearelasticityofexvivomousemuscles AT rdeluca measuringandmodellingnonlinearelasticityofexvivomousemuscles AT amusaro measuringandmodellingnonlinearelasticityofexvivomousemuscles AT zdelprete measuringandmodellingnonlinearelasticityofexvivomousemuscles
_version_	1718407688857059328

Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles

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