The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells

Abstract Six essential oils (from oregano, thyme, clove, lavender, clary sage, and arborvitae) exhibited different antibacterial and antifungal properties. Antimicrobial activity was shown against pathogenic (Escherichia coli, Salmonella typhimurium, Yersinia enterocolitica, Staphylococcus aureus, L...

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Autores principales:	Andrea Puškárová, Mária Bučková, Lucia Kraková, Domenico Pangallo, Katarína Kozics
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a13edbcfb3e4436a27d19d38acdb028
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spelling	oai:doaj.org-article:0a13edbcfb3e4436a27d19d38acdb0282021-12-02T15:18:52ZThe antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells10.1038/s41598-017-08673-92045-2322https://doaj.org/article/0a13edbcfb3e4436a27d19d38acdb0282017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08673-9https://doaj.org/toc/2045-2322Abstract Six essential oils (from oregano, thyme, clove, lavender, clary sage, and arborvitae) exhibited different antibacterial and antifungal properties. Antimicrobial activity was shown against pathogenic (Escherichia coli, Salmonella typhimurium, Yersinia enterocolitica, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis) and environmental bacteria (Bacillus cereus, Arthrobacter protophormiae, Pseudomonas fragi) and fungi (Chaetomium globosum, Penicillium chrysogenum, Cladosporium cladosporoides, Alternaria alternata, and Aspergillus fumigatus). Oregano, thyme, clove and arborvitae showed very strong antibacterial activity against all tested strains at both full strength and reduced concentrations. These essential oils showed different fungistatic and fungicidal activities when tested by direct application and in the vapor phase. The genotoxic effects of these oils on HEL 12469 human embryo lung cells were evaluated using an alkaline comet assay for the first time, revealing that none of the oils induced significant DNA damage in vitro after 24 h. This study provides novel approaches for assessing the antimicrobial potential of essential oils in both direct contact and the vapor phase and also demonstrates the valuable properties of the phenol-free arborvitae oil. These results suggest that all the tested essential oils might be used as broad-spectrum anti-microbial agents for decontaminating an indoor environment.Andrea PuškárováMária BučkováLucia KrakováDomenico PangalloKatarína KozicsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Puškárová Mária Bučková Lucia Kraková Domenico Pangallo Katarína Kozics The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells
description	Abstract Six essential oils (from oregano, thyme, clove, lavender, clary sage, and arborvitae) exhibited different antibacterial and antifungal properties. Antimicrobial activity was shown against pathogenic (Escherichia coli, Salmonella typhimurium, Yersinia enterocolitica, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis) and environmental bacteria (Bacillus cereus, Arthrobacter protophormiae, Pseudomonas fragi) and fungi (Chaetomium globosum, Penicillium chrysogenum, Cladosporium cladosporoides, Alternaria alternata, and Aspergillus fumigatus). Oregano, thyme, clove and arborvitae showed very strong antibacterial activity against all tested strains at both full strength and reduced concentrations. These essential oils showed different fungistatic and fungicidal activities when tested by direct application and in the vapor phase. The genotoxic effects of these oils on HEL 12469 human embryo lung cells were evaluated using an alkaline comet assay for the first time, revealing that none of the oils induced significant DNA damage in vitro after 24 h. This study provides novel approaches for assessing the antimicrobial potential of essential oils in both direct contact and the vapor phase and also demonstrates the valuable properties of the phenol-free arborvitae oil. These results suggest that all the tested essential oils might be used as broad-spectrum anti-microbial agents for decontaminating an indoor environment.
format	article
author	Andrea Puškárová Mária Bučková Lucia Kraková Domenico Pangallo Katarína Kozics
author_facet	Andrea Puškárová Mária Bučková Lucia Kraková Domenico Pangallo Katarína Kozics
author_sort	Andrea Puškárová
title	The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells
title_short	The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells
title_full	The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells
title_fullStr	The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells
title_full_unstemmed	The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells
title_sort	antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human hel 12469 cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a13edbcfb3e4436a27d19d38acdb028
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The antibacterial and antifungal activity of six essential oils and their cyto/genotoxicity to human HEL 12469 cells

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