Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children

Hearing loss is a total or partial inability to hear. Approximately 5% of people worldwide experience this condition. Hearing capacity is closely related to language, social, and basic emotional development; hearing loss is particularly serious in children. The pathogenesis of childhood hearing loss...

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Autores principales:	Feng Liang, Xin Fu, ShiJian Ding, Lin Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hearing loss children random walk with restart protein-protein interaction biomarker Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0a16eff7fb2248869c04fc5f278f3421
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id	oai:doaj.org-article:0a16eff7fb2248869c04fc5f278f3421
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spelling	oai:doaj.org-article:0a16eff7fb2248869c04fc5f278f34212021-12-01T13:23:26ZUse of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children2296-634X10.3389/fcell.2021.783500https://doaj.org/article/0a16eff7fb2248869c04fc5f278f34212021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.783500/fullhttps://doaj.org/toc/2296-634XHearing loss is a total or partial inability to hear. Approximately 5% of people worldwide experience this condition. Hearing capacity is closely related to language, social, and basic emotional development; hearing loss is particularly serious in children. The pathogenesis of childhood hearing loss remains poorly understood. Here, we sought to identify new genes potentially associated with two types of hearing loss in children: congenital deafness and otitis media. We used a network-based method incorporating a random walk with restart algorithm, as well as a protein-protein interaction framework, to identify genes potentially associated with either pathogenesis. A following screening procedure was performed and 18 and 87 genes were identified, which potentially involved in the development of congenital deafness or otitis media, respectively. These findings provide novel biomarkers for clinical screening of childhood deafness; they contribute to a genetic understanding of the pathogenetic mechanisms involved.Feng LiangXin FuShiJian DingLin LiFrontiers Media S.A.articlehearing losschildrenrandom walk with restartprotein-protein interactionbiomarkerBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hearing loss children random walk with restart protein-protein interaction biomarker Biology (General) QH301-705.5
spellingShingle	hearing loss children random walk with restart protein-protein interaction biomarker Biology (General) QH301-705.5 Feng Liang Xin Fu ShiJian Ding Lin Li Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children
description	Hearing loss is a total or partial inability to hear. Approximately 5% of people worldwide experience this condition. Hearing capacity is closely related to language, social, and basic emotional development; hearing loss is particularly serious in children. The pathogenesis of childhood hearing loss remains poorly understood. Here, we sought to identify new genes potentially associated with two types of hearing loss in children: congenital deafness and otitis media. We used a network-based method incorporating a random walk with restart algorithm, as well as a protein-protein interaction framework, to identify genes potentially associated with either pathogenesis. A following screening procedure was performed and 18 and 87 genes were identified, which potentially involved in the development of congenital deafness or otitis media, respectively. These findings provide novel biomarkers for clinical screening of childhood deafness; they contribute to a genetic understanding of the pathogenetic mechanisms involved.
format	article
author	Feng Liang Xin Fu ShiJian Ding Lin Li
author_facet	Feng Liang Xin Fu ShiJian Ding Lin Li
author_sort	Feng Liang
title	Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children
title_short	Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children
title_full	Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children
title_fullStr	Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children
title_full_unstemmed	Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children
title_sort	use of a network-based method to identify latent genes associated with hearing loss in children
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0a16eff7fb2248869c04fc5f278f3421
work_keys_str_mv	AT fengliang useofanetworkbasedmethodtoidentifylatentgenesassociatedwithhearinglossinchildren AT xinfu useofanetworkbasedmethodtoidentifylatentgenesassociatedwithhearinglossinchildren AT shijianding useofanetworkbasedmethodtoidentifylatentgenesassociatedwithhearinglossinchildren AT linli useofanetworkbasedmethodtoidentifylatentgenesassociatedwithhearinglossinchildren
_version_	1718405098907893760

Use of a Network-Based Method to Identify Latent Genes Associated with Hearing Loss in Children

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