Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells
Natural Killer cell development is controlled by two related transcription factors, Eomes and T-bet. Authors show here that while the two factors share a large proportion of their target genes, they regulate distinct developmental processes by differing in their pattern of expression and in their as...
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Nature Portfolio
2021
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oai:doaj.org-article:0a1b6ee2a9a04c48998d4f888c12b9302021-12-02T18:02:32ZSequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells10.1038/s41467-021-25758-22041-1723https://doaj.org/article/0a1b6ee2a9a04c48998d4f888c12b9302021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25758-2https://doaj.org/toc/2041-1723Natural Killer cell development is controlled by two related transcription factors, Eomes and T-bet. Authors show here that while the two factors share a large proportion of their target genes, they regulate distinct developmental processes by differing in their pattern of expression and in their associated co-factors.Jiang ZhangStéphanie Le GrasKevin PouxvielhFabrice FaureLucie FalloneNicolas KernMarion MoreewsAnne-Laure MathieuRaphaël SchneiderQuentin MarliacMathieu JungAurore BertonSimon HayekPierre-Olivier VidalainAntoine MarçaisGarvin DodardAnne DejeanLaurent BrossayYad Ghavi-HelmThierry WalzerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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Science Q Jiang Zhang Stéphanie Le Gras Kevin Pouxvielh Fabrice Faure Lucie Fallone Nicolas Kern Marion Moreews Anne-Laure Mathieu Raphaël Schneider Quentin Marliac Mathieu Jung Aurore Berton Simon Hayek Pierre-Olivier Vidalain Antoine Marçais Garvin Dodard Anne Dejean Laurent Brossay Yad Ghavi-Helm Thierry Walzer Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells |
| description |
Natural Killer cell development is controlled by two related transcription factors, Eomes and T-bet. Authors show here that while the two factors share a large proportion of their target genes, they regulate distinct developmental processes by differing in their pattern of expression and in their associated co-factors. |
| format |
article |
| author |
Jiang Zhang Stéphanie Le Gras Kevin Pouxvielh Fabrice Faure Lucie Fallone Nicolas Kern Marion Moreews Anne-Laure Mathieu Raphaël Schneider Quentin Marliac Mathieu Jung Aurore Berton Simon Hayek Pierre-Olivier Vidalain Antoine Marçais Garvin Dodard Anne Dejean Laurent Brossay Yad Ghavi-Helm Thierry Walzer |
| author_facet |
Jiang Zhang Stéphanie Le Gras Kevin Pouxvielh Fabrice Faure Lucie Fallone Nicolas Kern Marion Moreews Anne-Laure Mathieu Raphaël Schneider Quentin Marliac Mathieu Jung Aurore Berton Simon Hayek Pierre-Olivier Vidalain Antoine Marçais Garvin Dodard Anne Dejean Laurent Brossay Yad Ghavi-Helm Thierry Walzer |
| author_sort |
Jiang Zhang |
| title |
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells |
| title_short |
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells |
| title_full |
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells |
| title_fullStr |
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells |
| title_full_unstemmed |
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells |
| title_sort |
sequential actions of eomes and t-bet promote stepwise maturation of natural killer cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/0a1b6ee2a9a04c48998d4f888c12b930 |
| work_keys_str_mv |
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1718378850262450176 |