A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan

Wei Zhao,1,* Jing-Jing Tong,2,* Yong-Tong Cao,1 Jing-Hua Li1 1Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China; 2Liver Failure Treatment and Research Center, The Fifth Medical Center of PLA General Hospital, Beijing 100039, Peop...

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Autores principales:	Zhao W, Tong JJ, Cao YT, Li JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	absi type 2 diabetes linear relationship a retrospective cohort study Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0a1b91a8c2534ef097a155a913029388
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spelling	oai:doaj.org-article:0a1b91a8c2534ef097a155a9130293882021-12-02T11:16:11ZA Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan1178-7007https://doaj.org/article/0a1b91a8c2534ef097a155a9130293882020-06-01T00:00:00Zhttps://www.dovepress.com/a-linear-relationship-between-a-body-shape-index-and-risk-of-incident--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Wei Zhao,1,* Jing-Jing Tong,2,* Yong-Tong Cao,1 Jing-Hua Li1 1Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China; 2Liver Failure Treatment and Research Center, The Fifth Medical Center of PLA General Hospital, Beijing 100039, People’s Republic of China*These authors contributed equally to this workCorrespondence : Jing-Hua Li; Yong-Tong CaoDepartment of Clinical Laboratory, China-Japan Friendship Hospital, No. 2 Yinghua Road, Chaoyang District, Beijing 100029, People’s Republic of ChinaTel +86 108 420 5486; +86 108 420 5580Email lijinghua620524@163.com; caoyongtong100@sina.comPurpose: This study aimed to evaluate the association between a body shape index (ABSI) and incident type 2 diabetes and to explore the shape of their relationship in a cohort of Japanese adults.Patients and Methods: Data from 15,462 Japanese adults aged 18– 79 years attending the NAGALA study (NAfld in the Gifu Area, Longitudinal Analysis) were used. Body weight, height, and waist circumference were measured. Blood samples were measured for serum lipid, glucose, and HbA1c. The risk of incident type 2 diabetes according to ABSI was estimated using multivariate Cox regression models. We examined a potential nonlinear relationship using a smoothing function analysis. Subgroup analyses were conducted according to age, gender, smoking status, alcohol intake, fatty liver, and BMI.Results: After adjusting for potential confounding factors (age, gender, smoking status, alcohol intake, fatty liver, systolic blood pressure, BMI, fasting plasma glucose, HbA1c, HDL-cholesterol, triglycerides), a linear relationship was observed between ABSI and risk of type 2 diabetes. The hazard ratio (HR) and 95% confidence intervals (95% CI) for incident type 2 diabetes with ABSI (10− 2 m11/6kg− 2/3) were 1.51 (1.13, 2.01) (p=0.005). When ABSI was handled as categorical variable, the HRs and 95% CIs in the quartile 2 to 4 versus the quartile 1 were 0.97 (0.67, 1.41), 1.21 (0.85, 1.72) and 1.30 (0.92, 1.83), respectively (P for trend = 0.046). Subgroup analyses showed that the association stably existed in different subgroups including gender, age, smoking status, alcohol intake, fatty liver, and BMI.Conclusion: ABSI was linearly associated with an elevated risk of incident type 2 diabetes across the full range of ABSI, independent of gender, age, smoking status, alcohol intake, fatty liver, SBP, BMI, FPG, HbA1c, HDL-cholesterol, and triglycerides.Keywords: ABSI, type 2 diabetes, linear relationship, a retrospective cohort studyZhao WTong JJCao YTLi JHDove Medical Pressarticleabsitype 2 diabeteslinear relationshipa retrospective cohort studySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2139-2146 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	absi type 2 diabetes linear relationship a retrospective cohort study Specialties of internal medicine RC581-951
spellingShingle	absi type 2 diabetes linear relationship a retrospective cohort study Specialties of internal medicine RC581-951 Zhao W Tong JJ Cao YT Li JH A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan
description	Wei Zhao,1,* Jing-Jing Tong,2,* Yong-Tong Cao,1 Jing-Hua Li1 1Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China; 2Liver Failure Treatment and Research Center, The Fifth Medical Center of PLA General Hospital, Beijing 100039, People’s Republic of China*These authors contributed equally to this workCorrespondence : Jing-Hua Li; Yong-Tong CaoDepartment of Clinical Laboratory, China-Japan Friendship Hospital, No. 2 Yinghua Road, Chaoyang District, Beijing 100029, People’s Republic of ChinaTel +86 108 420 5486; +86 108 420 5580Email lijinghua620524@163.com; caoyongtong100@sina.comPurpose: This study aimed to evaluate the association between a body shape index (ABSI) and incident type 2 diabetes and to explore the shape of their relationship in a cohort of Japanese adults.Patients and Methods: Data from 15,462 Japanese adults aged 18– 79 years attending the NAGALA study (NAfld in the Gifu Area, Longitudinal Analysis) were used. Body weight, height, and waist circumference were measured. Blood samples were measured for serum lipid, glucose, and HbA1c. The risk of incident type 2 diabetes according to ABSI was estimated using multivariate Cox regression models. We examined a potential nonlinear relationship using a smoothing function analysis. Subgroup analyses were conducted according to age, gender, smoking status, alcohol intake, fatty liver, and BMI.Results: After adjusting for potential confounding factors (age, gender, smoking status, alcohol intake, fatty liver, systolic blood pressure, BMI, fasting plasma glucose, HbA1c, HDL-cholesterol, triglycerides), a linear relationship was observed between ABSI and risk of type 2 diabetes. The hazard ratio (HR) and 95% confidence intervals (95% CI) for incident type 2 diabetes with ABSI (10− 2 m11/6kg− 2/3) were 1.51 (1.13, 2.01) (p=0.005). When ABSI was handled as categorical variable, the HRs and 95% CIs in the quartile 2 to 4 versus the quartile 1 were 0.97 (0.67, 1.41), 1.21 (0.85, 1.72) and 1.30 (0.92, 1.83), respectively (P for trend = 0.046). Subgroup analyses showed that the association stably existed in different subgroups including gender, age, smoking status, alcohol intake, fatty liver, and BMI.Conclusion: ABSI was linearly associated with an elevated risk of incident type 2 diabetes across the full range of ABSI, independent of gender, age, smoking status, alcohol intake, fatty liver, SBP, BMI, FPG, HbA1c, HDL-cholesterol, and triglycerides.Keywords: ABSI, type 2 diabetes, linear relationship, a retrospective cohort study
format	article
author	Zhao W Tong JJ Cao YT Li JH
author_facet	Zhao W Tong JJ Cao YT Li JH
author_sort	Zhao W
title	A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan
title_short	A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan
title_full	A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan
title_fullStr	A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan
title_full_unstemmed	A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan
title_sort	linear relationship between a body shape index and risk of incident type 2 diabetes: a secondary analysis based on a retrospective cohort study in japan
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0a1b91a8c2534ef097a155a913029388
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A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan

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