Spinal cord demyelination combined with hyperhomocysteinemia: a case report

Meimei Hao, Yan Zhang, Shuangxing Hou, Yanling Chen, Ming Shi, Gang Zhao, Yanchun Deng Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Hyperhomocysteinemia (HHcy) has been recognized as an indepe...

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Autores principales:	Hao MM, Zhang Y, Hou SX, Chen YL, Shi M, Zhao G, Deng YC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0a20619a4216453491c7db7024999d27
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spelling	oai:doaj.org-article:0a20619a4216453491c7db7024999d272021-12-02T00:01:17ZSpinal cord demyelination combined with hyperhomocysteinemia: a case report1178-2021https://doaj.org/article/0a20619a4216453491c7db7024999d272014-11-01T00:00:00Zhttp://www.dovepress.com/spinal-cord-demyelination-combined-with-hyperhomocysteinemia-a-case-re-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Meimei Hao, Yan Zhang, Shuangxing Hou, Yanling Chen, Ming Shi, Gang Zhao, Yanchun Deng Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Hyperhomocysteinemia (HHcy) has been recognized as an independent risk factor for atherosclerotic vascular disease. Here we report a patient who suffered from spinal cord demyelination combined with HHcy. The patient was admitted to our hospital with a diagnosis of acute myelitis. However, hormone therapy was ineffective. Further investigations revealed that he had HHcy and a homozygous mutation of the gene encoding methylenetetrahydrofolate reductase (MTHFR) c.677C>T, which is a key enzyme involved in homocysteine metabolism. In view of these findings, we treated the patient with B vitamins and his symptoms gradually improved. Spinal magnetic resonance imaging performed 3 months after onset showed near recovery of the lesion. To our knowledge, similar reports are rare. Keywords: demyelination, hyperhomocysteinemia, homocysteine, methylenetetrahydrofolate reductase, methylationHao MMZhang YHou SXChen YLShi MZhao GDeng YCDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 2057-2059 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hao MM Zhang Y Hou SX Chen YL Shi M Zhao G Deng YC Spinal cord demyelination combined with hyperhomocysteinemia: a case report
description	Meimei Hao, Yan Zhang, Shuangxing Hou, Yanling Chen, Ming Shi, Gang Zhao, Yanchun Deng Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China Abstract: Hyperhomocysteinemia (HHcy) has been recognized as an independent risk factor for atherosclerotic vascular disease. Here we report a patient who suffered from spinal cord demyelination combined with HHcy. The patient was admitted to our hospital with a diagnosis of acute myelitis. However, hormone therapy was ineffective. Further investigations revealed that he had HHcy and a homozygous mutation of the gene encoding methylenetetrahydrofolate reductase (MTHFR) c.677C>T, which is a key enzyme involved in homocysteine metabolism. In view of these findings, we treated the patient with B vitamins and his symptoms gradually improved. Spinal magnetic resonance imaging performed 3 months after onset showed near recovery of the lesion. To our knowledge, similar reports are rare. Keywords: demyelination, hyperhomocysteinemia, homocysteine, methylenetetrahydrofolate reductase, methylation
format	article
author	Hao MM Zhang Y Hou SX Chen YL Shi M Zhao G Deng YC
author_facet	Hao MM Zhang Y Hou SX Chen YL Shi M Zhao G Deng YC
author_sort	Hao MM
title	Spinal cord demyelination combined with hyperhomocysteinemia: a case report
title_short	Spinal cord demyelination combined with hyperhomocysteinemia: a case report
title_full	Spinal cord demyelination combined with hyperhomocysteinemia: a case report
title_fullStr	Spinal cord demyelination combined with hyperhomocysteinemia: a case report
title_full_unstemmed	Spinal cord demyelination combined with hyperhomocysteinemia: a case report
title_sort	spinal cord demyelination combined with hyperhomocysteinemia: a case report
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0a20619a4216453491c7db7024999d27
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Spinal cord demyelination combined with hyperhomocysteinemia: a case report

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