Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women

Oxidative stress (OS) increases during the human aging process, and the sedentary lifestyle could be a prooxidant factor. In this study, we determine the effect of sedentary lifestyle on OS during the aging process in Mexican women. A longitudinal study of two-year follow-up was carried out with 177...

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Autores principales:	Martha A. Sánchez-Rodríguez, Mariano Zacarías-Flores, Elsa Correa-Muñoz, Alicia Arronte-Rosales, Víctor Manuel Mendoza-Núñez
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/0a225ab697f843b2aeb90bd69544c7e0
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spelling	oai:doaj.org-article:0a225ab697f843b2aeb90bd69544c7e02021-11-08T02:37:21ZOxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women1942-099410.1155/2021/9971765https://doaj.org/article/0a225ab697f843b2aeb90bd69544c7e02021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9971765https://doaj.org/toc/1942-0994Oxidative stress (OS) increases during the human aging process, and the sedentary lifestyle could be a prooxidant factor. In this study, we determine the effect of sedentary lifestyle on OS during the aging process in Mexican women. A longitudinal study of two-year follow-up was carried out with 177 community-dwelling women (40-69 y) from Mexico City. We measured as OS markers plasma malondialdehyde, erythrocyte glutathione peroxidase (GPx) and superoxide dismutase (SOD), total plasma antioxidant status, uric acid level, antioxidant gap, and SOD/GPx ratio. To define OS using all the markers, we defined cut-off values of each parameter based on the 90th percentile of young healthy subjects and, we calculated a stress score (SS) ranging from 0 to 7, which represented the intensity of the marker modifications. All the women answered a structured questionnaire about prooxidant factors, including physical activity specially the type of activity, frequency, and duration, and they answered Spanish versions of self-assessment tests for establishing dysthymia and insomnia as potential confounders. Principal component and Poisson regression analysis were used as statistical tools, being two-year OS the primary outcome. The OS was considerate as SS≥4 and sedentary lifestyle as <30 min/day of physical activity, beside several prooxidant factors and age that were covariables. SS is higher in sedentary lifestyle women after the two-year follow-up; although, the difference was statistically significant only in older women. Four principal components were associated with the OS, and 7 out of 8 prooxidant factors were important for the analysis, which were included in the Poisson model. The predictive factors for OS were the sedentary lifestyle (adjusted PR = 2.37, CI95%: 1.30–4.30, p<0.01), and age, in which the risk increases 1.06 (CI95%:1.02–2.11, p<0.01) by each year of age. Our findings suggest that a sedentary lifestyle increases the OS during the aging in Mexican women.Martha A. Sánchez-RodríguezMariano Zacarías-FloresElsa Correa-MuñozAlicia Arronte-RosalesVíctor Manuel Mendoza-NúñezHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Martha A. Sánchez-Rodríguez Mariano Zacarías-Flores Elsa Correa-Muñoz Alicia Arronte-Rosales Víctor Manuel Mendoza-Núñez Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women
description	Oxidative stress (OS) increases during the human aging process, and the sedentary lifestyle could be a prooxidant factor. In this study, we determine the effect of sedentary lifestyle on OS during the aging process in Mexican women. A longitudinal study of two-year follow-up was carried out with 177 community-dwelling women (40-69 y) from Mexico City. We measured as OS markers plasma malondialdehyde, erythrocyte glutathione peroxidase (GPx) and superoxide dismutase (SOD), total plasma antioxidant status, uric acid level, antioxidant gap, and SOD/GPx ratio. To define OS using all the markers, we defined cut-off values of each parameter based on the 90th percentile of young healthy subjects and, we calculated a stress score (SS) ranging from 0 to 7, which represented the intensity of the marker modifications. All the women answered a structured questionnaire about prooxidant factors, including physical activity specially the type of activity, frequency, and duration, and they answered Spanish versions of self-assessment tests for establishing dysthymia and insomnia as potential confounders. Principal component and Poisson regression analysis were used as statistical tools, being two-year OS the primary outcome. The OS was considerate as SS≥4 and sedentary lifestyle as <30 min/day of physical activity, beside several prooxidant factors and age that were covariables. SS is higher in sedentary lifestyle women after the two-year follow-up; although, the difference was statistically significant only in older women. Four principal components were associated with the OS, and 7 out of 8 prooxidant factors were important for the analysis, which were included in the Poisson model. The predictive factors for OS were the sedentary lifestyle (adjusted PR = 2.37, CI95%: 1.30–4.30, p<0.01), and age, in which the risk increases 1.06 (CI95%:1.02–2.11, p<0.01) by each year of age. Our findings suggest that a sedentary lifestyle increases the OS during the aging in Mexican women.
format	article
author	Martha A. Sánchez-Rodríguez Mariano Zacarías-Flores Elsa Correa-Muñoz Alicia Arronte-Rosales Víctor Manuel Mendoza-Núñez
author_facet	Martha A. Sánchez-Rodríguez Mariano Zacarías-Flores Elsa Correa-Muñoz Alicia Arronte-Rosales Víctor Manuel Mendoza-Núñez
author_sort	Martha A. Sánchez-Rodríguez
title	Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women
title_short	Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women
title_full	Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women
title_fullStr	Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women
title_full_unstemmed	Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women
title_sort	oxidative stress risk is increased with a sedentary lifestyle during aging in mexican women
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/0a225ab697f843b2aeb90bd69544c7e0
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Oxidative Stress Risk Is Increased with a Sedentary Lifestyle during Aging in Mexican Women

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