The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations

Abstract Genome-wide association studies identified that the common T of rs12143842 in NOS1AP is associated with a QT/QTc interval in European populations. In this study, we test the association between the variation rs12143842 in NOS1AP and idiopathic ventricular tachycardia (IVT). A case-control a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ronfeng Zhang, Feifei Chen, Honjiu Yu, Lianjun Gao, Xiaomeng Yin, Yingxue Dong, Yanzong Yang, Yunlong Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a2276964f4b413e8586d55e0549851f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0a2276964f4b413e8586d55e0549851f
record_format	dspace
spelling	oai:doaj.org-article:0a2276964f4b413e8586d55e0549851f2021-12-02T12:32:58ZThe genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations10.1038/s41598-017-08548-z2045-2322https://doaj.org/article/0a2276964f4b413e8586d55e0549851f2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08548-zhttps://doaj.org/toc/2045-2322Abstract Genome-wide association studies identified that the common T of rs12143842 in NOS1AP is associated with a QT/QTc interval in European populations. In this study, we test the association between the variation rs12143842 in NOS1AP and idiopathic ventricular tachycardia (IVT). A case-control association study examining rs12143842 was performed in two independent cohorts. The Northern cohort enrolled 277 IVT patients and 728 controls from a Chinese Gene ID population. The Central cohort enrolled 301 IVT patients and 803 matched controls. Genotyping was performed using high-resolution melt analysis. The minor T allele of the rs12143842 SNP was significantly associated with decreased IVT risk in the Northern cohort (adjusted P = 0.024, OR 0.71(0.52~0.96)), and this association was replicated in an independent Central Gene ID cohort (adjusted P = 0.029, OR 0.78 (0.62~0.97)). The association was more significant in the combined population (adjusted P = 0.001, OR 0.76 (0.64~0.90)). The P values for the genotypic association were significant for the dominant (P < 0.001) and additive (P = 0.001) models. The minor T allele for the SNP rs12143842 in NOS1AP is significantly associated with IVT. NOS1AP might be a novel gene affecting IVT, and further functional studies should be performed.Ronfeng ZhangFeifei ChenHonjiu YuLianjun GaoXiaomeng YinYingxue DongYanzong YangYunlong XiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ronfeng Zhang Feifei Chen Honjiu Yu Lianjun Gao Xiaomeng Yin Yingxue Dong Yanzong Yang Yunlong Xia The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations
description	Abstract Genome-wide association studies identified that the common T of rs12143842 in NOS1AP is associated with a QT/QTc interval in European populations. In this study, we test the association between the variation rs12143842 in NOS1AP and idiopathic ventricular tachycardia (IVT). A case-control association study examining rs12143842 was performed in two independent cohorts. The Northern cohort enrolled 277 IVT patients and 728 controls from a Chinese Gene ID population. The Central cohort enrolled 301 IVT patients and 803 matched controls. Genotyping was performed using high-resolution melt analysis. The minor T allele of the rs12143842 SNP was significantly associated with decreased IVT risk in the Northern cohort (adjusted P = 0.024, OR 0.71(0.52~0.96)), and this association was replicated in an independent Central Gene ID cohort (adjusted P = 0.029, OR 0.78 (0.62~0.97)). The association was more significant in the combined population (adjusted P = 0.001, OR 0.76 (0.64~0.90)). The P values for the genotypic association were significant for the dominant (P < 0.001) and additive (P = 0.001) models. The minor T allele for the SNP rs12143842 in NOS1AP is significantly associated with IVT. NOS1AP might be a novel gene affecting IVT, and further functional studies should be performed.
format	article
author	Ronfeng Zhang Feifei Chen Honjiu Yu Lianjun Gao Xiaomeng Yin Yingxue Dong Yanzong Yang Yunlong Xia
author_facet	Ronfeng Zhang Feifei Chen Honjiu Yu Lianjun Gao Xiaomeng Yin Yingxue Dong Yanzong Yang Yunlong Xia
author_sort	Ronfeng Zhang
title	The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations
title_short	The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations
title_full	The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations
title_fullStr	The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations
title_full_unstemmed	The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations
title_sort	genetic variation rs12143842 in nos1ap increases idiopathic ventricular tachycardia risk in chinese han populations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a2276964f4b413e8586d55e0549851f
work_keys_str_mv	AT ronfengzhang thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT feifeichen thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT honjiuyu thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT lianjungao thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT xiaomengyin thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT yingxuedong thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT yanzongyang thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT yunlongxia thegeneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT ronfengzhang geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT feifeichen geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT honjiuyu geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT lianjungao geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT xiaomengyin geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT yingxuedong geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT yanzongyang geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations AT yunlongxia geneticvariationrs12143842innos1apincreasesidiopathicventriculartachycardiariskinchinesehanpopulations
_version_	1718393899808980992

The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations

Ejemplares similares