Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage

Abstract Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was...

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Autores principales:	Sverre Wikström, Ghada Hussein, Annika Lingroth Karlsson, Christian H. Lindh, Carl-Gustaf Bornehag
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a228697439a42f593eb4507a1bbd407
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spelling	oai:doaj.org-article:0a228697439a42f593eb4507a1bbd4072021-12-02T13:30:18ZExposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage10.1038/s41598-021-82748-62045-2322https://doaj.org/article/0a228697439a42f593eb4507a1bbd4072021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82748-6https://doaj.org/toc/2045-2322Abstract Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester miscarriage were included and 1449 women were available as live birth controls. Eight PFASs were measured in first trimester serum. A doubling of perfluorooctanoic acid (PFOA) exposure, corresponding to an inter-quartile increase, was associated with an odds ratio (95%CI) for miscarriage of 1.48 (1.09–2.01) when adjusting for parity, age and smoking. Analyses per quartiles of PFOA exposure indicated a monotonic dose response association with miscarriage. A similar, but not significant, pattern was observed for perfluorononanoic acid (PFNA). For other PFAS, there were no associations with miscarriage. We have previously shown associations between early pregnancy PFAS exposures and preeclampsia, as well as lower birth weight. Now we report an association between PFOA and miscarriage within the same cohort, which may suggest shared but unknown mechanisms. The study can only represent a period of early placentation and clinical pregnancy loss during the second half of the first trimester.Sverre WikströmGhada HusseinAnnika Lingroth KarlssonChristian H. LindhCarl-Gustaf BornehagNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sverre Wikström Ghada Hussein Annika Lingroth Karlsson Christian H. Lindh Carl-Gustaf Bornehag Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
description	Abstract Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester miscarriage were included and 1449 women were available as live birth controls. Eight PFASs were measured in first trimester serum. A doubling of perfluorooctanoic acid (PFOA) exposure, corresponding to an inter-quartile increase, was associated with an odds ratio (95%CI) for miscarriage of 1.48 (1.09–2.01) when adjusting for parity, age and smoking. Analyses per quartiles of PFOA exposure indicated a monotonic dose response association with miscarriage. A similar, but not significant, pattern was observed for perfluorononanoic acid (PFNA). For other PFAS, there were no associations with miscarriage. We have previously shown associations between early pregnancy PFAS exposures and preeclampsia, as well as lower birth weight. Now we report an association between PFOA and miscarriage within the same cohort, which may suggest shared but unknown mechanisms. The study can only represent a period of early placentation and clinical pregnancy loss during the second half of the first trimester.
format	article
author	Sverre Wikström Ghada Hussein Annika Lingroth Karlsson Christian H. Lindh Carl-Gustaf Bornehag
author_facet	Sverre Wikström Ghada Hussein Annika Lingroth Karlsson Christian H. Lindh Carl-Gustaf Bornehag
author_sort	Sverre Wikström
title	Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
title_short	Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
title_full	Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
title_fullStr	Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
title_full_unstemmed	Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
title_sort	exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a228697439a42f593eb4507a1bbd407
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Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage

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