Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model

Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model

Abstract Primary ovarian insufficiency (POI) is defined as the loss of ovarian function before 40 years of age. It clinically manifests as amenorrhea, infertility, and signs of estrogen insufficiency. POI is frequently induced by chemotherapy. Gonadotoxic chemotherapy reagents damage granulosa cells...

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Autores principales: Hang-soo Park, Rishi Man Chugh, Abdeljabar El Andaloussi, Elie Hobeika, Sahar Esfandyari, Amro Elsharoud, Mara Ulin, Natalia Garcia, Mahmood Bilal, Ayman Al-Hendy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0a255be30f734959be08103720a68858
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