Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies

This review aimed to systematically review observational studies investigating the longitudinal association between anxiety, depression and quality of life (QoL). A systematic search of five electronic databases (PubMed, PsycINFO, PSYNDEX, NHS EED and EconLit) as well as forward/backward reference s...

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Autores principales:	Johanna Katharina Hohls, Hans-Helmut König, Eleanor Quirke, André Hajek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anxiety depression quality of life systematic review meta-analysis longitudinal study Medicine R
Acceso en línea:	https://doaj.org/article/0a26998378e147d58966ec11ebdfb2ec
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spelling	oai:doaj.org-article:0a26998378e147d58966ec11ebdfb2ec2021-11-25T17:50:25ZAnxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies10.3390/ijerph1822120221660-46011661-7827https://doaj.org/article/0a26998378e147d58966ec11ebdfb2ec2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/12022https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601This review aimed to systematically review observational studies investigating the longitudinal association between anxiety, depression and quality of life (QoL). A systematic search of five electronic databases (PubMed, PsycINFO, PSYNDEX, NHS EED and EconLit) as well as forward/backward reference searches were conducted to identify observational studies on the longitudinal association between anxiety, depression and QoL. Studies were synthesized narratively. Additionally, a random-effects meta-analysis was performed using studies applying the mental and physical summary scores (MCS, PCS) of the Short Form Health Survey. The review was prospectively registered with PROSPERO and a study protocol was published. <i>n</i> = 47 studies on heterogeneous research questions were included, with sample sizes ranging from <i>n</i> = 28 to 43,093. Narrative synthesis indicated that QoL was reduced before disorder onset, dropped further during the disorder and improved with remission. Before onset and after remission, QoL was lower in comparison to healthy comparisons. <i>n</i> = 8 studies were included in random-effects meta-analyses. The pooled estimates of QoL at follow-up (FU) were of small to large effect sizes and showed that QoL at FU differed by disorder status at baseline as well as by disorder course over time. Disorder course groups differed in their MCS scores at baseline. Effect sizes were generally larger for MCS relative to PCS. The results highlight the relevance of preventive measures and treatment. Future research should consider individual QoL domains, individual anxiety/depressive disorders as well as the course of both over time to allow more differentiated statements in a meta-analysis.Johanna Katharina HohlsHans-Helmut KönigEleanor QuirkeAndré HajekMDPI AGarticleanxietydepressionquality of lifesystematic reviewmeta-analysislongitudinal studyMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 12022, p 12022 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety depression quality of life systematic review meta-analysis longitudinal study Medicine R
spellingShingle	anxiety depression quality of life systematic review meta-analysis longitudinal study Medicine R Johanna Katharina Hohls Hans-Helmut König Eleanor Quirke André Hajek Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies
description	This review aimed to systematically review observational studies investigating the longitudinal association between anxiety, depression and quality of life (QoL). A systematic search of five electronic databases (PubMed, PsycINFO, PSYNDEX, NHS EED and EconLit) as well as forward/backward reference searches were conducted to identify observational studies on the longitudinal association between anxiety, depression and QoL. Studies were synthesized narratively. Additionally, a random-effects meta-analysis was performed using studies applying the mental and physical summary scores (MCS, PCS) of the Short Form Health Survey. The review was prospectively registered with PROSPERO and a study protocol was published. <i>n</i> = 47 studies on heterogeneous research questions were included, with sample sizes ranging from <i>n</i> = 28 to 43,093. Narrative synthesis indicated that QoL was reduced before disorder onset, dropped further during the disorder and improved with remission. Before onset and after remission, QoL was lower in comparison to healthy comparisons. <i>n</i> = 8 studies were included in random-effects meta-analyses. The pooled estimates of QoL at follow-up (FU) were of small to large effect sizes and showed that QoL at FU differed by disorder status at baseline as well as by disorder course over time. Disorder course groups differed in their MCS scores at baseline. Effect sizes were generally larger for MCS relative to PCS. The results highlight the relevance of preventive measures and treatment. Future research should consider individual QoL domains, individual anxiety/depressive disorders as well as the course of both over time to allow more differentiated statements in a meta-analysis.
format	article
author	Johanna Katharina Hohls Hans-Helmut König Eleanor Quirke André Hajek
author_facet	Johanna Katharina Hohls Hans-Helmut König Eleanor Quirke André Hajek
author_sort	Johanna Katharina Hohls
title	Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies
title_short	Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies
title_full	Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies
title_fullStr	Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies
title_full_unstemmed	Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies
title_sort	anxiety, depression and quality of life—a systematic review of evidence from longitudinal observational studies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0a26998378e147d58966ec11ebdfb2ec
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Anxiety, Depression and Quality of Life—A Systematic Review of Evidence from Longitudinal Observational Studies

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