Adiponectin as a novel biomarker of disease severity in alopecia areata

Abstract The frequent coexistence of obesity and metabolic syndrome in patients with alopecia areata may indicate the common pathogenetic pathway in these conditions with an important role of adipokines. The aim of the study was to evaluate the serum level of adiponectin, resistin and leptin in pati...

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Autores principales:	Anna Stochmal, Anna Waśkiel-Burnat, Sylwia Chrostowska, Michał Zaremba, Adriana Rakowska, Joanna Czuwara, Lidia Rudnicka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a270bdb89554f7c96d8a24c4f407feb
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spelling	oai:doaj.org-article:0a270bdb89554f7c96d8a24c4f407feb2021-12-02T16:14:46ZAdiponectin as a novel biomarker of disease severity in alopecia areata10.1038/s41598-021-92853-12045-2322https://doaj.org/article/0a270bdb89554f7c96d8a24c4f407feb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92853-1https://doaj.org/toc/2045-2322Abstract The frequent coexistence of obesity and metabolic syndrome in patients with alopecia areata may indicate the common pathogenetic pathway in these conditions with an important role of adipokines. The aim of the study was to evaluate the serum level of adiponectin, resistin and leptin in patients with alopecia areata in comparison to healthy controls. The study included 65 patients with alopecia areata and 71 healthy controls. The concentration of adipokines was determined with the enzyme-linked immunosorbent assay. The mean concentrations of adiponectin and resistin were significantly lower in the sera of patients with alopecia areata when compared to healthy controls (7966 $$\pm$$ ± 4087 vs 9947 $$\pm$$ ± 5692 ng/ml; p = 0.0312 and 11.04 $$\pm$$ ± 3.88 vs 14.11 $$\pm$$ ± 8.69 ng/ml; p = 0.0176, respectively). A negative correlation between the serum level of adiponectin and severity of alopecia tool (SALT) score was observed (r = − 0.26; p < 0.05). The concentration of adiponectin was significantly lower in patients with alopecia universalis than in patients with patchy alopecia areata (4951 $$\pm$$ ± 2499 vs 8525 $$\pm$$ ± 4085 ng/ml; p = 0.0135). No significant difference in the serum concentration of leptin was observed between patients with alopecia areata and healthy controls. The negative correlation between the serum level of adiponectin and hair loss severity indicates that adiponectin may be considered a marker of hair loss severity in alopecia areata. Further studies are needed to evaluate the role of resistin in patients with alopecia areata and its decreased level irregardless of severity or activity of the disease.Anna StochmalAnna Waśkiel-BurnatSylwia ChrostowskaMichał ZarembaAdriana RakowskaJoanna CzuwaraLidia RudnickaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Stochmal Anna Waśkiel-Burnat Sylwia Chrostowska Michał Zaremba Adriana Rakowska Joanna Czuwara Lidia Rudnicka Adiponectin as a novel biomarker of disease severity in alopecia areata
description	Abstract The frequent coexistence of obesity and metabolic syndrome in patients with alopecia areata may indicate the common pathogenetic pathway in these conditions with an important role of adipokines. The aim of the study was to evaluate the serum level of adiponectin, resistin and leptin in patients with alopecia areata in comparison to healthy controls. The study included 65 patients with alopecia areata and 71 healthy controls. The concentration of adipokines was determined with the enzyme-linked immunosorbent assay. The mean concentrations of adiponectin and resistin were significantly lower in the sera of patients with alopecia areata when compared to healthy controls (7966 $$\pm$$ ± 4087 vs 9947 $$\pm$$ ± 5692 ng/ml; p = 0.0312 and 11.04 $$\pm$$ ± 3.88 vs 14.11 $$\pm$$ ± 8.69 ng/ml; p = 0.0176, respectively). A negative correlation between the serum level of adiponectin and severity of alopecia tool (SALT) score was observed (r = − 0.26; p < 0.05). The concentration of adiponectin was significantly lower in patients with alopecia universalis than in patients with patchy alopecia areata (4951 $$\pm$$ ± 2499 vs 8525 $$\pm$$ ± 4085 ng/ml; p = 0.0135). No significant difference in the serum concentration of leptin was observed between patients with alopecia areata and healthy controls. The negative correlation between the serum level of adiponectin and hair loss severity indicates that adiponectin may be considered a marker of hair loss severity in alopecia areata. Further studies are needed to evaluate the role of resistin in patients with alopecia areata and its decreased level irregardless of severity or activity of the disease.
format	article
author	Anna Stochmal Anna Waśkiel-Burnat Sylwia Chrostowska Michał Zaremba Adriana Rakowska Joanna Czuwara Lidia Rudnicka
author_facet	Anna Stochmal Anna Waśkiel-Burnat Sylwia Chrostowska Michał Zaremba Adriana Rakowska Joanna Czuwara Lidia Rudnicka
author_sort	Anna Stochmal
title	Adiponectin as a novel biomarker of disease severity in alopecia areata
title_short	Adiponectin as a novel biomarker of disease severity in alopecia areata
title_full	Adiponectin as a novel biomarker of disease severity in alopecia areata
title_fullStr	Adiponectin as a novel biomarker of disease severity in alopecia areata
title_full_unstemmed	Adiponectin as a novel biomarker of disease severity in alopecia areata
title_sort	adiponectin as a novel biomarker of disease severity in alopecia areata
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a270bdb89554f7c96d8a24c4f407feb
work_keys_str_mv	AT annastochmal adiponectinasanovelbiomarkerofdiseaseseverityinalopeciaareata AT annawaskielburnat adiponectinasanovelbiomarkerofdiseaseseverityinalopeciaareata AT sylwiachrostowska adiponectinasanovelbiomarkerofdiseaseseverityinalopeciaareata AT michałzaremba adiponectinasanovelbiomarkerofdiseaseseverityinalopeciaareata AT adrianarakowska adiponectinasanovelbiomarkerofdiseaseseverityinalopeciaareata AT joannaczuwara adiponectinasanovelbiomarkerofdiseaseseverityinalopeciaareata AT lidiarudnicka adiponectinasanovelbiomarkerofdiseaseseverityinalopeciaareata
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Adiponectin as a novel biomarker of disease severity in alopecia areata

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