Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages

Ovarian cancer cells often metastasize to the peritoneal cavity, forming spheroid-like structures and promoting a highly immunosuppressive tumor microenvironment. Here, the authors show that the ubiquitin ligase UBR5 is required for ovarian cancer growth and metastasis, sustaining spheroid formation...

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Autores principales:	Mei Song, Oladapo O. Yeku, Sarwish Rafiq, Terence Purdon, Xue Dong, Lijing Zhu, Tuo Zhang, Huan Wang, Ziqi Yu, Junhua Mai, Haifa Shen, Briana Nixon, Ming Li, Renier J. Brentjens, Xiaojing Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0a29ad9f32554973937d9a3a66e49066
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spelling	oai:doaj.org-article:0a29ad9f32554973937d9a3a66e490662021-12-02T10:48:29ZTumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages10.1038/s41467-020-20140-02041-1723https://doaj.org/article/0a29ad9f32554973937d9a3a66e490662020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20140-0https://doaj.org/toc/2041-1723Ovarian cancer cells often metastasize to the peritoneal cavity, forming spheroid-like structures and promoting a highly immunosuppressive tumor microenvironment. Here, the authors show that the ubiquitin ligase UBR5 is required for ovarian cancer growth and metastasis, sustaining spheroid formation and the infiltration of immunosuppressive tumor associated macrophages.Mei SongOladapo O. YekuSarwish RafiqTerence PurdonXue DongLijing ZhuTuo ZhangHuan WangZiqi YuJunhua MaiHaifa ShenBriana NixonMing LiRenier J. BrentjensXiaojing MaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mei Song Oladapo O. Yeku Sarwish Rafiq Terence Purdon Xue Dong Lijing Zhu Tuo Zhang Huan Wang Ziqi Yu Junhua Mai Haifa Shen Briana Nixon Ming Li Renier J. Brentjens Xiaojing Ma Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
description	Ovarian cancer cells often metastasize to the peritoneal cavity, forming spheroid-like structures and promoting a highly immunosuppressive tumor microenvironment. Here, the authors show that the ubiquitin ligase UBR5 is required for ovarian cancer growth and metastasis, sustaining spheroid formation and the infiltration of immunosuppressive tumor associated macrophages.
format	article
author	Mei Song Oladapo O. Yeku Sarwish Rafiq Terence Purdon Xue Dong Lijing Zhu Tuo Zhang Huan Wang Ziqi Yu Junhua Mai Haifa Shen Briana Nixon Ming Li Renier J. Brentjens Xiaojing Ma
author_facet	Mei Song Oladapo O. Yeku Sarwish Rafiq Terence Purdon Xue Dong Lijing Zhu Tuo Zhang Huan Wang Ziqi Yu Junhua Mai Haifa Shen Briana Nixon Ming Li Renier J. Brentjens Xiaojing Ma
author_sort	Mei Song
title	Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
title_short	Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
title_full	Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
title_fullStr	Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
title_full_unstemmed	Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
title_sort	tumor derived ubr5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0a29ad9f32554973937d9a3a66e49066
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Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages

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