First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder

Objective We examined whether the anti‐saccade task (AST) performance after the first methylphenidate (MPH) dose could be associated with subsequent clinical outcome in adults with attention‐deficit/hyperactivity disorder (ADHD). Methods Ninety‐seven drug‐naive DSM‐5 ADHD adults participated in this...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fabrice Duval, Alexis Erb, Marie‐Claude Mokrani, Thomas Weiss, Roberta Carcangiu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/0a2c861d2a6a4175a4959ca69d172432
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0a2c861d2a6a4175a4959ca69d172432
record_format	dspace
spelling	oai:doaj.org-article:0a2c861d2a6a4175a4959ca69d1724322021-12-02T13:52:49ZFirst‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder2575-560910.1176/appi.prcp.20210010https://doaj.org/article/0a2c861d2a6a4175a4959ca69d1724322021-12-01T00:00:00Zhttps://doi.org/10.1176/appi.prcp.20210010https://doaj.org/toc/2575-5609Objective We examined whether the anti‐saccade task (AST) performance after the first methylphenidate (MPH) dose could be associated with subsequent clinical outcome in adults with attention‐deficit/hyperactivity disorder (ADHD). Methods Ninety‐seven drug‐naive DSM‐5 ADHD adults participated in this study. The AST parameters were measured at baseline, after the first MPH‐dose (10 mg orally), and 6 months after chronic MPH treatment. Results were compared with those of 50 healthy control (HC) subjects. Results At baseline, ADHDs showed longer saccadic reaction times and more direction errors than HCs (both p < 0.00001). Acute and chronic MPH administration resulted in normalization of the AST performances. Multivariate regression analysis after adjusting for age, sex, weight, and severity of symptoms at baseline, revealed that a low percentage of direction errors after the first MPH‐dose (i.e., ≤10%) could predict remission at month 6 (OR: 5.84; 95% CI: 2.00–17.11; p = 0.001). Conclusions Our findings indicate that: (1) impairments of motor planning and response inhibition in adults with ADHD are improved with MPH, and (2) a low direction error percentage after the first MPH‐dose may be an independent predictor of remission. ClinicalTrials.gov identifier: NCT03411434Fabrice DuvalAlexis ErbMarie‐Claude MokraniThomas WeissRoberta CarcangiuWileyarticlePsychiatryRC435-571ENPsychiatric Research and Clinical Practice, Vol 3, Iss 4, Pp 146-152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Fabrice Duval Alexis Erb Marie‐Claude Mokrani Thomas Weiss Roberta Carcangiu First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder
description	Objective We examined whether the anti‐saccade task (AST) performance after the first methylphenidate (MPH) dose could be associated with subsequent clinical outcome in adults with attention‐deficit/hyperactivity disorder (ADHD). Methods Ninety‐seven drug‐naive DSM‐5 ADHD adults participated in this study. The AST parameters were measured at baseline, after the first MPH‐dose (10 mg orally), and 6 months after chronic MPH treatment. Results were compared with those of 50 healthy control (HC) subjects. Results At baseline, ADHDs showed longer saccadic reaction times and more direction errors than HCs (both p < 0.00001). Acute and chronic MPH administration resulted in normalization of the AST performances. Multivariate regression analysis after adjusting for age, sex, weight, and severity of symptoms at baseline, revealed that a low percentage of direction errors after the first MPH‐dose (i.e., ≤10%) could predict remission at month 6 (OR: 5.84; 95% CI: 2.00–17.11; p = 0.001). Conclusions Our findings indicate that: (1) impairments of motor planning and response inhibition in adults with ADHD are improved with MPH, and (2) a low direction error percentage after the first MPH‐dose may be an independent predictor of remission. ClinicalTrials.gov identifier: NCT03411434
format	article
author	Fabrice Duval Alexis Erb Marie‐Claude Mokrani Thomas Weiss Roberta Carcangiu
author_facet	Fabrice Duval Alexis Erb Marie‐Claude Mokrani Thomas Weiss Roberta Carcangiu
author_sort	Fabrice Duval
title	First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder
title_short	First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder
title_full	First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder
title_fullStr	First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder
title_full_unstemmed	First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder
title_sort	first‐dose methylphenidate‐induced changes in the anti‐saccade task performance and outcome in adults with attention‐deficit/hyperactivity disorder
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/0a2c861d2a6a4175a4959ca69d172432
work_keys_str_mv	AT fabriceduval firstdosemethylphenidateinducedchangesintheantisaccadetaskperformanceandoutcomeinadultswithattentiondeficithyperactivitydisorder AT alexiserb firstdosemethylphenidateinducedchangesintheantisaccadetaskperformanceandoutcomeinadultswithattentiondeficithyperactivitydisorder AT marieclaudemokrani firstdosemethylphenidateinducedchangesintheantisaccadetaskperformanceandoutcomeinadultswithattentiondeficithyperactivitydisorder AT thomasweiss firstdosemethylphenidateinducedchangesintheantisaccadetaskperformanceandoutcomeinadultswithattentiondeficithyperactivitydisorder AT robertacarcangiu firstdosemethylphenidateinducedchangesintheantisaccadetaskperformanceandoutcomeinadultswithattentiondeficithyperactivitydisorder
_version_	1718392360613707776

First‐Dose Methylphenidate‐Induced Changes in the Anti‐Saccade Task Performance and Outcome in Adults with Attention‐Deficit/Hyperactivity Disorder

Ejemplares similares