Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies

Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalong...

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Autores principales:	Thet D, Siritientong T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0a2e16924bd342a88eef019f06ce9829
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spelling	oai:doaj.org-article:0a2e16924bd342a88eef019f06ce98292021-12-02T11:59:46ZAntiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies1179-1373https://doaj.org/article/0a2e16924bd342a88eef019f06ce98292020-10-01T00:00:00Zhttps://www.dovepress.com/antiretroviral-therapy-associated-metabolic-complications-review-of-th-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.s@pharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profileThet DSiritientong TDove Medical Pressarticlehivantiretroviral therapylipodystrophymetaboliclipid profileImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 507-524 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy RC581-607
spellingShingle	hiv antiretroviral therapy lipodystrophy metabolic lipid profile Immunologic diseases. Allergy RC581-607 Thet D Siritientong T Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
description	Daylia Thet, Tippawan Siritientong Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandCorrespondence: Tippawan SiritientongDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, ThailandTel +6661-956-2898Fax +662-218-8291Email tippawan.s@pharm.chula.ac.thAbstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile
format	article
author	Thet D Siritientong T
author_facet	Thet D Siritientong T
author_sort	Thet D
title	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
title_short	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
title_full	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
title_fullStr	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
title_full_unstemmed	Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies
title_sort	antiretroviral therapy-associated metabolic complications: review of the recent studies
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0a2e16924bd342a88eef019f06ce9829
work_keys_str_mv	AT thetd antiretroviraltherapyassociatedmetaboliccomplicationsreviewoftherecentstudies AT siritientongt antiretroviraltherapyassociatedmetaboliccomplicationsreviewoftherecentstudies
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Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies

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