Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial

Abstract Physical frailty and nutritional malassimilation are often observed after pancreaticoduodenectomy for pancreatic cancer. But long-term data concerning the course of micronutrient status is still missing. Micronutrient status after pylorus preserving pancreaticoduodenectomy with a follow-up...

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Autores principales:	Navid Tabriz, Verena Nicole Uslar, Dennis Obonyo, Dirk Weyhe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a2e708ac56b4cd68bbc7e657cf106c3
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spelling	oai:doaj.org-article:0a2e708ac56b4cd68bbc7e657cf106c32021-12-02T18:02:15ZMicronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial10.1038/s41598-021-97438-62045-2322https://doaj.org/article/0a2e708ac56b4cd68bbc7e657cf106c32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97438-6https://doaj.org/toc/2045-2322Abstract Physical frailty and nutritional malassimilation are often observed after pancreaticoduodenectomy for pancreatic cancer. But long-term data concerning the course of micronutrient status is still missing. Micronutrient status after pylorus preserving pancreaticoduodenectomy with a follow-up of 12 months was evaluated using data of a randomized controlled trial. 47 patients were randomized with respect to the physiotherapy regimen they received (intensified physiotherapy: n = 22; standard physiotherapy: n = 25). Nutritional status was recorded preoperatively and postoperatively after one week, 3, 6 and 12 months. BMI, body fat measurement and albumin, lipid, iron and bone metabolism parameters, vitamins A, B1 B6 and B12, homocysteine, folic acid, and trace elements were measured. Laboratory values were analyzed descriptively. Differences between the groups were analyzed using the t-test in SPSS. For vitamin D, B1, B6 and iron a deficiency over time could be demonstrated with 50% of all patients or more being below normal range. The other laboratory values were in low normal range after 3 months and later. Significant differences between groups were found in cholesterol, HDL and selenium levels (corrected p-values < 0.033 in all cases). Vitamin D and iron should be supplemented postoperatively in the long term, and vitamin B1 and B6 substitution should be considered in symptomatic patients. Levels of malnutrition induced fatigue should be comparable between both groups. However, the role of nutritional status on other health-related aspects such as quality of life should be the focus of further studies. Trial Registration Number in the German Registry for Clinical Studies: DRKS00006786; Date of Registration: 01.10.2014.Navid TabrizVerena Nicole UslarDennis ObonyoDirk WeyheNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Navid Tabriz Verena Nicole Uslar Dennis Obonyo Dirk Weyhe Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial
description	Abstract Physical frailty and nutritional malassimilation are often observed after pancreaticoduodenectomy for pancreatic cancer. But long-term data concerning the course of micronutrient status is still missing. Micronutrient status after pylorus preserving pancreaticoduodenectomy with a follow-up of 12 months was evaluated using data of a randomized controlled trial. 47 patients were randomized with respect to the physiotherapy regimen they received (intensified physiotherapy: n = 22; standard physiotherapy: n = 25). Nutritional status was recorded preoperatively and postoperatively after one week, 3, 6 and 12 months. BMI, body fat measurement and albumin, lipid, iron and bone metabolism parameters, vitamins A, B1 B6 and B12, homocysteine, folic acid, and trace elements were measured. Laboratory values were analyzed descriptively. Differences between the groups were analyzed using the t-test in SPSS. For vitamin D, B1, B6 and iron a deficiency over time could be demonstrated with 50% of all patients or more being below normal range. The other laboratory values were in low normal range after 3 months and later. Significant differences between groups were found in cholesterol, HDL and selenium levels (corrected p-values < 0.033 in all cases). Vitamin D and iron should be supplemented postoperatively in the long term, and vitamin B1 and B6 substitution should be considered in symptomatic patients. Levels of malnutrition induced fatigue should be comparable between both groups. However, the role of nutritional status on other health-related aspects such as quality of life should be the focus of further studies. Trial Registration Number in the German Registry for Clinical Studies: DRKS00006786; Date of Registration: 01.10.2014.
format	article
author	Navid Tabriz Verena Nicole Uslar Dennis Obonyo Dirk Weyhe
author_facet	Navid Tabriz Verena Nicole Uslar Dennis Obonyo Dirk Weyhe
author_sort	Navid Tabriz
title	Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial
title_short	Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial
title_full	Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial
title_fullStr	Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial
title_full_unstemmed	Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial
title_sort	micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a2e708ac56b4cd68bbc7e657cf106c3
work_keys_str_mv	AT navidtabriz micronutritionalstatusafterpyloruspreservingduodenopancreatectomyanalysisofdatafromarandomizedcontrolledtrial AT verenanicoleuslar micronutritionalstatusafterpyloruspreservingduodenopancreatectomyanalysisofdatafromarandomizedcontrolledtrial AT dennisobonyo micronutritionalstatusafterpyloruspreservingduodenopancreatectomyanalysisofdatafromarandomizedcontrolledtrial AT dirkweyhe micronutritionalstatusafterpyloruspreservingduodenopancreatectomyanalysisofdatafromarandomizedcontrolledtrial
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Micronutritional status after pylorus preserving duodenopancreatectomy: analysis of data from a randomized controlled trial

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