Gut microbiota of liver transplantation recipients

Abstract The characteristics of intestinal microbial communities may be affected by changes in the pathophysiology of patients with end-stage liver disease. Here, we focused on the characteristics of intestinal fecal microbial communities in post-liver transplantation (LT) patients in comparison wit...

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Autores principales:	Li-Ying Sun, Yun-Sheng Yang, Wei Qu, Zhi-Jun Zhu, Lin Wei, Zhi-Sheng Ye, Jian-Rui Zhang, Xiao-Ye Sun, Zhi-Gui Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a2eaebf74a94feeac9b4803ecd1f1eb
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spelling	oai:doaj.org-article:0a2eaebf74a94feeac9b4803ecd1f1eb2021-12-02T16:08:22ZGut microbiota of liver transplantation recipients10.1038/s41598-017-03476-42045-2322https://doaj.org/article/0a2eaebf74a94feeac9b4803ecd1f1eb2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03476-4https://doaj.org/toc/2045-2322Abstract The characteristics of intestinal microbial communities may be affected by changes in the pathophysiology of patients with end-stage liver disease. Here, we focused on the characteristics of intestinal fecal microbial communities in post-liver transplantation (LT) patients in comparison with those in the same individuals pre-LT and in healthy individuals. The fecal microbial communities were analyzed via MiSeq-PE250 sequencing of the V4 region of 16S ribosomal RNA and were then compared between groups. We found that the gut microbiota of patients with severe liver disease who were awaiting LT was significantly different from that of healthy controls, as represented by the first principal component (p = 0.0066). Additionally, the second principal component represented a significant difference in the gut microbiota of patients between pre-LT and post-LT surgery (p = 0.03125). After LT, there was a significant decrease in the abundance of certain microbial species, such as Actinobacillus, Escherichia, and Shigella, and a significant increase in the abundance of other microbial species, such as Micromonosporaceae, Desulfobacterales, the Sarcina genus of Eubacteriaceae, and Akkermansia. Based on KEGG profiles, 15 functional modules were enriched and 21 functional modules were less represented in the post-LT samples compared with the pre-LT samples. Our study demonstrates that fecal microbial communities were significantly altered by LT.Li-Ying SunYun-Sheng YangWei QuZhi-Jun ZhuLin WeiZhi-Sheng YeJian-Rui ZhangXiao-Ye SunZhi-Gui ZengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li-Ying Sun Yun-Sheng Yang Wei Qu Zhi-Jun Zhu Lin Wei Zhi-Sheng Ye Jian-Rui Zhang Xiao-Ye Sun Zhi-Gui Zeng Gut microbiota of liver transplantation recipients
description	Abstract The characteristics of intestinal microbial communities may be affected by changes in the pathophysiology of patients with end-stage liver disease. Here, we focused on the characteristics of intestinal fecal microbial communities in post-liver transplantation (LT) patients in comparison with those in the same individuals pre-LT and in healthy individuals. The fecal microbial communities were analyzed via MiSeq-PE250 sequencing of the V4 region of 16S ribosomal RNA and were then compared between groups. We found that the gut microbiota of patients with severe liver disease who were awaiting LT was significantly different from that of healthy controls, as represented by the first principal component (p = 0.0066). Additionally, the second principal component represented a significant difference in the gut microbiota of patients between pre-LT and post-LT surgery (p = 0.03125). After LT, there was a significant decrease in the abundance of certain microbial species, such as Actinobacillus, Escherichia, and Shigella, and a significant increase in the abundance of other microbial species, such as Micromonosporaceae, Desulfobacterales, the Sarcina genus of Eubacteriaceae, and Akkermansia. Based on KEGG profiles, 15 functional modules were enriched and 21 functional modules were less represented in the post-LT samples compared with the pre-LT samples. Our study demonstrates that fecal microbial communities were significantly altered by LT.
format	article
author	Li-Ying Sun Yun-Sheng Yang Wei Qu Zhi-Jun Zhu Lin Wei Zhi-Sheng Ye Jian-Rui Zhang Xiao-Ye Sun Zhi-Gui Zeng
author_facet	Li-Ying Sun Yun-Sheng Yang Wei Qu Zhi-Jun Zhu Lin Wei Zhi-Sheng Ye Jian-Rui Zhang Xiao-Ye Sun Zhi-Gui Zeng
author_sort	Li-Ying Sun
title	Gut microbiota of liver transplantation recipients
title_short	Gut microbiota of liver transplantation recipients
title_full	Gut microbiota of liver transplantation recipients
title_fullStr	Gut microbiota of liver transplantation recipients
title_full_unstemmed	Gut microbiota of liver transplantation recipients
title_sort	gut microbiota of liver transplantation recipients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a2eaebf74a94feeac9b4803ecd1f1eb
work_keys_str_mv	AT liyingsun gutmicrobiotaoflivertransplantationrecipients AT yunshengyang gutmicrobiotaoflivertransplantationrecipients AT weiqu gutmicrobiotaoflivertransplantationrecipients AT zhijunzhu gutmicrobiotaoflivertransplantationrecipients AT linwei gutmicrobiotaoflivertransplantationrecipients AT zhishengye gutmicrobiotaoflivertransplantationrecipients AT jianruizhang gutmicrobiotaoflivertransplantationrecipients AT xiaoyesun gutmicrobiotaoflivertransplantationrecipients AT zhiguizeng gutmicrobiotaoflivertransplantationrecipients
_version_	1718384513394933760

Gut microbiota of liver transplantation recipients

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