The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.

<h4>Purpose</h4>This study assessed the incidence and types of medication errors, interventions and outcomes in patients on antiretroviral therapy (ART) in selected HIV treatment centres in Nigeria.<h4>Methods</h4>Of 69 health facilities that had program for active screening...

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Autores principales: Kenneth Anene Agu, Dorothy Oqua, Zainab Adeyanju, Muhammadu Alfa Isah, Afusat Adesina, Samuel I Ohiaeri, Pollock N Ali, Nnenna Ekechukwu, Augustine Adah Akpakwu, Tindak Sani, Idoko Onuche Omeh, Rosalyn C King, Anthony K Wutoh
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:0a3372688ffc403e82f1376d271180ae2021-11-18T08:35:17ZThe incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.1932-620310.1371/journal.pone.0087338https://doaj.org/article/0a3372688ffc403e82f1376d271180ae2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24489899/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>This study assessed the incidence and types of medication errors, interventions and outcomes in patients on antiretroviral therapy (ART) in selected HIV treatment centres in Nigeria.<h4>Methods</h4>Of 69 health facilities that had program for active screening of medication errors, 14 were randomly selected for prospective cohort assessment. All patients who filled/refilled their antiretroviral medications between February 2009 and March 2011 were screened for medication errors using study-specific pharmaceutical care daily worksheet (PCDW). All potential or actual medication errors identified, interventions provided and the outcomes were documented in the PCDW. Interventions included pharmaceutical care in HIV training for pharmacists amongst others. Chi-square was used for inferential statistics and P<0.05 indicated statistical significance.<h4>Results</h4>Of 6,882 participants, 67.0% were female and 93.5% were aged ≥ 15 years old. The participants had 110,070 medications filling/refilling visits, average (± SD) of 16.0 (± 0.3) visits per patient over the observation period. Patients were followed up for 9172.5 person-years. The number of drug items dispensed to participants was 305,584, average of 2.8 (± 0.1) drug items per patient. The incidence rate of medication errors was 40.5 per 100 person-years. The occurrence of medication errors was not associated with participants' sex and age (P>0.05). The major medications errors identified were 26.4% incorrect ART regimens prescribed; 19.8% potential drug-drug interaction or contraindication present; and 16.6% duration and/or frequency of medication inappropriate. Interventions provided included 67.1% cases of prescriber contacted to clarify/resolve errors and 14.7% cases of patient counselling and education; 97.4% of potential/actual medication error(s) were resolved.<h4>Conclusion</h4>The incidence rate of medication errors was somewhat high; and majority of identified errors were related to prescription of incorrect ART regimens and potential drug-drug interactions; the prescriber was contacted and the errors were resolved in majority of cases. Active screening for medication errors is feasible in resource-limited settings following a capacity building intervention.Kenneth Anene AguDorothy OquaZainab AdeyanjuMuhammadu Alfa IsahAfusat AdesinaSamuel I OhiaeriPollock N AliNnenna EkechukwuAugustine Adah AkpakwuTindak SaniIdoko Onuche OmehRosalyn C KingAnthony K WutohPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87338 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Kenneth Anene Agu
Dorothy Oqua
Zainab Adeyanju
Muhammadu Alfa Isah
Afusat Adesina
Samuel I Ohiaeri
Pollock N Ali
Nnenna Ekechukwu
Augustine Adah Akpakwu
Tindak Sani
Idoko Onuche Omeh
Rosalyn C King
Anthony K Wutoh
The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.
description <h4>Purpose</h4>This study assessed the incidence and types of medication errors, interventions and outcomes in patients on antiretroviral therapy (ART) in selected HIV treatment centres in Nigeria.<h4>Methods</h4>Of 69 health facilities that had program for active screening of medication errors, 14 were randomly selected for prospective cohort assessment. All patients who filled/refilled their antiretroviral medications between February 2009 and March 2011 were screened for medication errors using study-specific pharmaceutical care daily worksheet (PCDW). All potential or actual medication errors identified, interventions provided and the outcomes were documented in the PCDW. Interventions included pharmaceutical care in HIV training for pharmacists amongst others. Chi-square was used for inferential statistics and P<0.05 indicated statistical significance.<h4>Results</h4>Of 6,882 participants, 67.0% were female and 93.5% were aged ≥ 15 years old. The participants had 110,070 medications filling/refilling visits, average (± SD) of 16.0 (± 0.3) visits per patient over the observation period. Patients were followed up for 9172.5 person-years. The number of drug items dispensed to participants was 305,584, average of 2.8 (± 0.1) drug items per patient. The incidence rate of medication errors was 40.5 per 100 person-years. The occurrence of medication errors was not associated with participants' sex and age (P>0.05). The major medications errors identified were 26.4% incorrect ART regimens prescribed; 19.8% potential drug-drug interaction or contraindication present; and 16.6% duration and/or frequency of medication inappropriate. Interventions provided included 67.1% cases of prescriber contacted to clarify/resolve errors and 14.7% cases of patient counselling and education; 97.4% of potential/actual medication error(s) were resolved.<h4>Conclusion</h4>The incidence rate of medication errors was somewhat high; and majority of identified errors were related to prescription of incorrect ART regimens and potential drug-drug interactions; the prescriber was contacted and the errors were resolved in majority of cases. Active screening for medication errors is feasible in resource-limited settings following a capacity building intervention.
format article
author Kenneth Anene Agu
Dorothy Oqua
Zainab Adeyanju
Muhammadu Alfa Isah
Afusat Adesina
Samuel I Ohiaeri
Pollock N Ali
Nnenna Ekechukwu
Augustine Adah Akpakwu
Tindak Sani
Idoko Onuche Omeh
Rosalyn C King
Anthony K Wutoh
author_facet Kenneth Anene Agu
Dorothy Oqua
Zainab Adeyanju
Muhammadu Alfa Isah
Afusat Adesina
Samuel I Ohiaeri
Pollock N Ali
Nnenna Ekechukwu
Augustine Adah Akpakwu
Tindak Sani
Idoko Onuche Omeh
Rosalyn C King
Anthony K Wutoh
author_sort Kenneth Anene Agu
title The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.
title_short The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.
title_full The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.
title_fullStr The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.
title_full_unstemmed The incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.
title_sort incidence and types of medication errors in patients receiving antiretroviral therapy in resource-constrained settings.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/0a3372688ffc403e82f1376d271180ae
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