JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

Hye Kyung Lee et al. identify additional candidate enhancers linked to the ACE2 promoters producing biologically active ACE2, the receptor for SARS-CoV-2. They also demonstrate JAK inhibitors suppress the interferon-induced genetic programs, including ACE2 expression, in human airway epithelial cell...

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Autores principales:	Hye Kyung Lee, Olive Jung, Lothar Hennighausen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0a35be854af246e9b9e1fc24a7fb0df2
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spelling	oai:doaj.org-article:0a35be854af246e9b9e1fc24a7fb0df22021-12-02T18:25:02ZJAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells10.1038/s42003-021-02167-12399-3642https://doaj.org/article/0a35be854af246e9b9e1fc24a7fb0df22021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02167-1https://doaj.org/toc/2399-3642Hye Kyung Lee et al. identify additional candidate enhancers linked to the ACE2 promoters producing biologically active ACE2, the receptor for SARS-CoV-2. They also demonstrate JAK inhibitors suppress the interferon-induced genetic programs, including ACE2 expression, in human airway epithelial cells.Hye Kyung LeeOlive JungLothar HennighausenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hye Kyung Lee Olive Jung Lothar Hennighausen JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells
description	Hye Kyung Lee et al. identify additional candidate enhancers linked to the ACE2 promoters producing biologically active ACE2, the receptor for SARS-CoV-2. They also demonstrate JAK inhibitors suppress the interferon-induced genetic programs, including ACE2 expression, in human airway epithelial cells.
format	article
author	Hye Kyung Lee Olive Jung Lothar Hennighausen
author_facet	Hye Kyung Lee Olive Jung Lothar Hennighausen
author_sort	Hye Kyung Lee
title	JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells
title_short	JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells
title_full	JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells
title_fullStr	JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells
title_full_unstemmed	JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells
title_sort	jak inhibitors dampen activation of interferon-stimulated transcription of ace2 isoforms in human airway epithelial cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0a35be854af246e9b9e1fc24a7fb0df2
work_keys_str_mv	AT hyekyunglee jakinhibitorsdampenactivationofinterferonstimulatedtranscriptionoface2isoformsinhumanairwayepithelialcells AT olivejung jakinhibitorsdampenactivationofinterferonstimulatedtranscriptionoface2isoformsinhumanairwayepithelialcells AT lotharhennighausen jakinhibitorsdampenactivationofinterferonstimulatedtranscriptionoface2isoformsinhumanairwayepithelialcells
_version_	1718378020258971648

JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

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