Genome-wide association study of pancreatic cancer in Japanese population.

Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated w...

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Autores principales:	Siew-Kee Low, Aya Kuchiba, Hitoshi Zembutsu, Akira Saito, Atsushi Takahashi, Michiaki Kubo, Yataro Daigo, Naoyuki Kamatani, Suenori Chiku, Hirohiko Totsuka, Sumiko Ohnami, Hiroshi Hirose, Kazuaki Shimada, Takuji Okusaka, Teruhiko Yoshida, Yusuke Nakamura, Hiromi Sakamoto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a36769c6ab540d6a6e63b9cd2e23373
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spelling	oai:doaj.org-article:0a36769c6ab540d6a6e63b9cd2e233732021-11-18T06:36:36ZGenome-wide association study of pancreatic cancer in Japanese population.1932-620310.1371/journal.pone.0011824https://doaj.org/article/0a36769c6ab540d6a6e63b9cd2e233732010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20686608/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value<5x10(-7)) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30x10(-7), 3.30x10(-7), and 4.41x10(-7); located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.Siew-Kee LowAya KuchibaHitoshi ZembutsuAkira SaitoAtsushi TakahashiMichiaki KuboYataro DaigoNaoyuki KamataniSuenori ChikuHirohiko TotsukaSumiko OhnamiHiroshi HiroseKazuaki ShimadaTakuji OkusakaTeruhiko YoshidaYusuke NakamuraHiromi SakamotoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11824 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siew-Kee Low Aya Kuchiba Hitoshi Zembutsu Akira Saito Atsushi Takahashi Michiaki Kubo Yataro Daigo Naoyuki Kamatani Suenori Chiku Hirohiko Totsuka Sumiko Ohnami Hiroshi Hirose Kazuaki Shimada Takuji Okusaka Teruhiko Yoshida Yusuke Nakamura Hiromi Sakamoto Genome-wide association study of pancreatic cancer in Japanese population.
description	Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value<5x10(-7)) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30x10(-7), 3.30x10(-7), and 4.41x10(-7); located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
format	article
author	Siew-Kee Low Aya Kuchiba Hitoshi Zembutsu Akira Saito Atsushi Takahashi Michiaki Kubo Yataro Daigo Naoyuki Kamatani Suenori Chiku Hirohiko Totsuka Sumiko Ohnami Hiroshi Hirose Kazuaki Shimada Takuji Okusaka Teruhiko Yoshida Yusuke Nakamura Hiromi Sakamoto
author_facet	Siew-Kee Low Aya Kuchiba Hitoshi Zembutsu Akira Saito Atsushi Takahashi Michiaki Kubo Yataro Daigo Naoyuki Kamatani Suenori Chiku Hirohiko Totsuka Sumiko Ohnami Hiroshi Hirose Kazuaki Shimada Takuji Okusaka Teruhiko Yoshida Yusuke Nakamura Hiromi Sakamoto
author_sort	Siew-Kee Low
title	Genome-wide association study of pancreatic cancer in Japanese population.
title_short	Genome-wide association study of pancreatic cancer in Japanese population.
title_full	Genome-wide association study of pancreatic cancer in Japanese population.
title_fullStr	Genome-wide association study of pancreatic cancer in Japanese population.
title_full_unstemmed	Genome-wide association study of pancreatic cancer in Japanese population.
title_sort	genome-wide association study of pancreatic cancer in japanese population.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/0a36769c6ab540d6a6e63b9cd2e23373
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Genome-wide association study of pancreatic cancer in Japanese population.

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