Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients

Abstract Although previous studies demonstrated that elevated C-reactive protein to albumin ratio (CAR) predicted poor prognosis in various solid tumors, little was known about the prognostic value of CAR in patients with advanced pancreatic cancer (APC). The aim of the present study was to assess C...

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Autores principales:	Junjie Hang, Peng Xue, Haiyan Yang, Shaobo Li, Donghui Chen, Lifei Zhu, Weiyi Huang, Shujuan Ren, Yue Zhu, Liwei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0a3c15f328564a41ae32c012e1797ca1
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spelling	oai:doaj.org-article:0a3c15f328564a41ae32c012e1797ca12021-12-02T12:32:03ZPretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients10.1038/s41598-017-03153-62045-2322https://doaj.org/article/0a3c15f328564a41ae32c012e1797ca12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03153-6https://doaj.org/toc/2045-2322Abstract Although previous studies demonstrated that elevated C-reactive protein to albumin ratio (CAR) predicted poor prognosis in various solid tumors, little was known about the prognostic value of CAR in patients with advanced pancreatic cancer (APC). The aim of the present study was to assess CAR as one independent prognostic factor in predicting overall survival (OS) in APC patients who had received palliative chemotherapy. Data of 142 APC patients who received palliative chemotherapy between 2009 and 2014 were retrospectively documented. We classified the patients into two groups based on the optimal cutoff value of CAR identified by generating receiver operating characteristics (ROC) curve. The clinicopathological parameters were compared between two CAR groups. Pearson correlation test showed that the level of C-reactive protein (CRP) was inversely correlated with albumin (r = −0.387; P < 0.001). Kaplan-Meier analysis demonstrated overall survival (OS) was significantly longer in CAR < 0.156 group than CAR ≥ 0.156 group (11.2 vs 5.9 months, P < 0.001). CAR was an independent prognostic factor for OS in the Cox regression model (HR, 1.623; 95% CI, 1.093–2.410; P = 0.016). Furthermore, the discrimination ability of CAR (AUC = 0.648, P = 0.025) was slightly higher than that of other inflammation-based factors. Therefore, pretreatment CAR could be an independent prognostic biomarker for APC patients.Junjie HangPeng XueHaiyan YangShaobo LiDonghui ChenLifei ZhuWeiyi HuangShujuan RenYue ZhuLiwei WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junjie Hang Peng Xue Haiyan Yang Shaobo Li Donghui Chen Lifei Zhu Weiyi Huang Shujuan Ren Yue Zhu Liwei Wang Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients
description	Abstract Although previous studies demonstrated that elevated C-reactive protein to albumin ratio (CAR) predicted poor prognosis in various solid tumors, little was known about the prognostic value of CAR in patients with advanced pancreatic cancer (APC). The aim of the present study was to assess CAR as one independent prognostic factor in predicting overall survival (OS) in APC patients who had received palliative chemotherapy. Data of 142 APC patients who received palliative chemotherapy between 2009 and 2014 were retrospectively documented. We classified the patients into two groups based on the optimal cutoff value of CAR identified by generating receiver operating characteristics (ROC) curve. The clinicopathological parameters were compared between two CAR groups. Pearson correlation test showed that the level of C-reactive protein (CRP) was inversely correlated with albumin (r = −0.387; P < 0.001). Kaplan-Meier analysis demonstrated overall survival (OS) was significantly longer in CAR < 0.156 group than CAR ≥ 0.156 group (11.2 vs 5.9 months, P < 0.001). CAR was an independent prognostic factor for OS in the Cox regression model (HR, 1.623; 95% CI, 1.093–2.410; P = 0.016). Furthermore, the discrimination ability of CAR (AUC = 0.648, P = 0.025) was slightly higher than that of other inflammation-based factors. Therefore, pretreatment CAR could be an independent prognostic biomarker for APC patients.
format	article
author	Junjie Hang Peng Xue Haiyan Yang Shaobo Li Donghui Chen Lifei Zhu Weiyi Huang Shujuan Ren Yue Zhu Liwei Wang
author_facet	Junjie Hang Peng Xue Haiyan Yang Shaobo Li Donghui Chen Lifei Zhu Weiyi Huang Shujuan Ren Yue Zhu Liwei Wang
author_sort	Junjie Hang
title	Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients
title_short	Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients
title_full	Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients
title_fullStr	Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients
title_full_unstemmed	Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients
title_sort	pretreatment c-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0a3c15f328564a41ae32c012e1797ca1
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_version_	1718394139054178304

Pretreatment C-reactive protein to albumin ratio for predicting overall survival in advanced pancreatic cancer patients

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