APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Angela R Garcia, Caleb Finch, Margaret Gatz, Thomas Kraft, Daniel Eid Rodriguez, Daniel Cummings, Mia Charifson, Kenneth Buetow, Bret A Beheim, Hooman Allayee, Gregory S Thomas, Jonathan Stieglitz, Michael D Gurven, Hillard Kaplan, Benjamin C Trumble
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	APOE Alzheimer's disease dementia cardiovascular disease cholesterol inflammation Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0a3db5e60d954d4f846826abf855dc08
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0a3db5e60d954d4f846826abf855dc08
record_format	dspace
spelling	oai:doaj.org-article:0a3db5e60d954d4f846826abf855dc082021-11-25T10:20:53ZAPOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population10.7554/eLife.682312050-084Xe68231https://doaj.org/article/0a3db5e60d954d4f846826abf855dc082021-09-01T00:00:00Zhttps://elifesciences.org/articles/68231https://doaj.org/toc/2050-084XIn post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N = 1266, 50% female), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low body mass indices (BMIs). These results suggest that the relationship between APOE4 and lipids may be beneficial for pathogen-driven immune responses and unlikely to increase cardiovascular risk in an active subsistence population.Angela R GarciaCaleb FinchMargaret GatzThomas KraftDaniel Eid RodriguezDaniel CummingsMia CharifsonKenneth BuetowBret A BeheimHooman AllayeeGregory S ThomasJonathan StieglitzMichael D GurvenHillard KaplanBenjamin C TrumbleeLife Sciences Publications LtdarticleAPOEAlzheimer's diseasedementiacardiovascular diseasecholesterolinflammationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	APOE Alzheimer's disease dementia cardiovascular disease cholesterol inflammation Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	APOE Alzheimer's disease dementia cardiovascular disease cholesterol inflammation Medicine R Science Q Biology (General) QH301-705.5 Angela R Garcia Caleb Finch Margaret Gatz Thomas Kraft Daniel Eid Rodriguez Daniel Cummings Mia Charifson Kenneth Buetow Bret A Beheim Hooman Allayee Gregory S Thomas Jonathan Stieglitz Michael D Gurven Hillard Kaplan Benjamin C Trumble APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
description	In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N = 1266, 50% female), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low body mass indices (BMIs). These results suggest that the relationship between APOE4 and lipids may be beneficial for pathogen-driven immune responses and unlikely to increase cardiovascular risk in an active subsistence population.
format	article
author	Angela R Garcia Caleb Finch Margaret Gatz Thomas Kraft Daniel Eid Rodriguez Daniel Cummings Mia Charifson Kenneth Buetow Bret A Beheim Hooman Allayee Gregory S Thomas Jonathan Stieglitz Michael D Gurven Hillard Kaplan Benjamin C Trumble
author_facet	Angela R Garcia Caleb Finch Margaret Gatz Thomas Kraft Daniel Eid Rodriguez Daniel Cummings Mia Charifson Kenneth Buetow Bret A Beheim Hooman Allayee Gregory S Thomas Jonathan Stieglitz Michael D Gurven Hillard Kaplan Benjamin C Trumble
author_sort	Angela R Garcia
title	APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
title_short	APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
title_full	APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
title_fullStr	APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
title_full_unstemmed	APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
title_sort	apoe4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical amerindian subsistence population
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/0a3db5e60d954d4f846826abf855dc08
work_keys_str_mv	AT angelargarcia apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT calebfinch apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT margaretgatz apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT thomaskraft apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT danieleidrodriguez apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT danielcummings apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT miacharifson apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT kennethbuetow apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT bretabeheim apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT hoomanallayee apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT gregorysthomas apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT jonathanstieglitz apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT michaeldgurven apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT hillardkaplan apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation AT benjaminctrumble apoe4isassociatedwithelevatedbloodlipidsandlowerlevelsofinnateimmunebiomarkersinatropicalamerindiansubsistencepopulation
_version_	1718413539883876352

APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

Ejemplares similares