EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE

En este trabajo se describe la síntesis de hidrazonas derivadas de cromano, tiocromano, alquil y aril hidrazonas, su actividad leishmanicida y su efecto sobre proteasas de cisteína de L. (V) panamensis. Se sintetizan feniltiocromanos y bencil y naftil derivados; solamente las fenilhidrazonas muestra...

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Autores principales:	Diana L. MUÑOZ, Diana P. CARDONA, Alvaro CARDONA, Lina M. CARRILLO, Winston QUIÑONES, ECHEVERRI Fernando, Iván D. VÉLEZ, Sara M. ROBLEDO
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2006
Materias:	síntesis hidrazonas efecto leishmanicida proteasas de cisteína Leishmania (V) panamensis synthesis hydrazones leishmanicidal effect cystein proteases Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/0a403bae8d7f4ae19934794a4c91f5af
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spelling	oai:doaj.org-article:0a403bae8d7f4ae19934794a4c91f5af2021-12-02T08:49:11ZEFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE0121-4004https://doaj.org/article/0a403bae8d7f4ae19934794a4c91f5af2006-01-01T00:00:00Zhttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042006000200001https://doaj.org/toc/0121-4004En este trabajo se describe la síntesis de hidrazonas derivadas de cromano, tiocromano, alquil y aril hidrazonas, su actividad leishmanicida y su efecto sobre proteasas de cisteína de L. (V) panamensis. Se sintetizan feniltiocromanos y bencil y naftil derivados; solamente las fenilhidrazonas muestran alguna actividad sobre amastigotes de Leishmnia (V) panamensis. No se observa ningún efecto sobre una proteasa de cisteína del parásito lo que sugiere un mecanismo de acción diferente a la inhibición de esta enzima.<br>In this paper, the synthesis of hydrazones derived from cromano, thiocroman, alkyl and aril hydrazones is described, as well as their leishmanicidal activity and their effect on cysteine proteases from L. (V) panamensis. A series of novel phenylthiochromane and benzyl and naphtyl derivatives are synthesized and evaluated for their cytotoxic and antileishmanial activities. Their effect on parasite cysteine protease is also evaluated. Only phenylthiochromane derivatives display some activity against Leishmania (V) panamensis but all compounds are inactive against parasitic cystein protease. These results may suggest a different mechanism of action for these compounds.Diana L. MUÑOZDiana P. CARDONAAlvaro CARDONALina M. CARRILLOWinston QUIÑONESECHEVERRI FernandoIván D. VÉLEZSara M. ROBLEDOUniversidad de Antioquiaarticlesíntesishidrazonasefecto leishmanicidaproteasas de cisteínaLeishmania (V) panamensissynthesishydrazonesleishmanicidal effectcystein proteasesLeishmania (V) panamensisFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 13, Iss 2, Pp 05-12 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	síntesis hidrazonas efecto leishmanicida proteasas de cisteína Leishmania (V) panamensis synthesis hydrazones leishmanicidal effect cystein proteases Leishmania (V) panamensis Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	síntesis hidrazonas efecto leishmanicida proteasas de cisteína Leishmania (V) panamensis synthesis hydrazones leishmanicidal effect cystein proteases Leishmania (V) panamensis Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diana L. MUÑOZ Diana P. CARDONA Alvaro CARDONA Lina M. CARRILLO Winston QUIÑONES ECHEVERRI Fernando Iván D. VÉLEZ Sara M. ROBLEDO EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE
description	En este trabajo se describe la síntesis de hidrazonas derivadas de cromano, tiocromano, alquil y aril hidrazonas, su actividad leishmanicida y su efecto sobre proteasas de cisteína de L. (V) panamensis. Se sintetizan feniltiocromanos y bencil y naftil derivados; solamente las fenilhidrazonas muestran alguna actividad sobre amastigotes de Leishmnia (V) panamensis. No se observa ningún efecto sobre una proteasa de cisteína del parásito lo que sugiere un mecanismo de acción diferente a la inhibición de esta enzima.<br>In this paper, the synthesis of hydrazones derived from cromano, thiocroman, alkyl and aril hydrazones is described, as well as their leishmanicidal activity and their effect on cysteine proteases from L. (V) panamensis. A series of novel phenylthiochromane and benzyl and naphtyl derivatives are synthesized and evaluated for their cytotoxic and antileishmanial activities. Their effect on parasite cysteine protease is also evaluated. Only phenylthiochromane derivatives display some activity against Leishmania (V) panamensis but all compounds are inactive against parasitic cystein protease. These results may suggest a different mechanism of action for these compounds.
format	article
author	Diana L. MUÑOZ Diana P. CARDONA Alvaro CARDONA Lina M. CARRILLO Winston QUIÑONES ECHEVERRI Fernando Iván D. VÉLEZ Sara M. ROBLEDO
author_facet	Diana L. MUÑOZ Diana P. CARDONA Alvaro CARDONA Lina M. CARRILLO Winston QUIÑONES ECHEVERRI Fernando Iván D. VÉLEZ Sara M. ROBLEDO
author_sort	Diana L. MUÑOZ
title	EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE
title_short	EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE
title_full	EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE
title_fullStr	EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE
title_full_unstemmed	EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE
title_sort	efecto de hidrazonas sobre amastigotes intracelulares de leishmania panamensis y una proteasa de cisteína parasitaria effect of hydrazones against intracellular amastigotes of leishmania panamensis and a parasitic cystein protease
publisher	Universidad de Antioquia
publishDate	2006
url	https://doaj.org/article/0a403bae8d7f4ae19934794a4c91f5af
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EFECTO DE HIDRAZONAS SOBRE AMASTIGOTES INTRACELULARES DE Leishmania panamensis Y UNA PROTEASA DE CISTEÍNA PARASITARIA EFFECT OF HYDRAZONES AGAINST INTRACELLULAR AMASTIGOTES OF Leishmania panamensis AND A PARASITIC CYSTEIN PROTEASE

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