Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
Borneol, a traditional Chinese medicine, can enhance therapeutic efficacy by guiding the active ingredients to the target site. Reportedly, borneol improves the penetration capacity of the nasal, cornea, transdermal, intestinal, and blood-brain barriers. Although nanotechnology dramatically changed...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:0a41460089944094a44208f9d40865172021-11-30T23:55:55ZRecent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System2296-858X10.3389/fmed.2021.750170https://doaj.org/article/0a41460089944094a44208f9d40865172021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.750170/fullhttps://doaj.org/toc/2296-858XBorneol, a traditional Chinese medicine, can enhance therapeutic efficacy by guiding the active ingredients to the target site. Reportedly, borneol improves the penetration capacity of the nasal, cornea, transdermal, intestinal, and blood-brain barriers. Although nanotechnology dramatically changed the face of oncology by targeting tumor sites, the efficiency of nanoparticles delivered to tumor sites is very low, with only 0.7% of the total particles delivered. Thus, based on the penetration ability and the inhibition drug efflux of borneol, it was expected to increase the targeting and detention efficacy of drugs into tumor sites in nanocarriers with borneol modification. Borneol modified nanocarriers used to improve drug-targeting has become a research focus in recent years, but few studies in this area, especially in the antitumor application. Hence, this review summarizes the recent development of nanocarriers with borneol modification. We focus on the updated works of improving therapeutic efficacy, reducing toxicity, inhibiting tumor metastasis, reversing multidrug resistance, and enhancing brain targeting to expand their application and provide a reference for further exploration of targeting drug delivery systems for solid tumor treatment.Jinxiu LiJinxiu LiQian XieQian XieRong MaRong MaYong LiYong LiJianmei YuanJianmei YuanMihong RenMihong RenHongyan LiHongyan LiJiajun WangJiajun WangDanni LuDanni LuZhuo XuZhuo XuJian WangJian WangFrontiers Media S.A.articleborneolnanocarrierdrug deliverytargetingdrug resistancetumor therapyMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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borneol nanocarrier drug delivery targeting drug resistance tumor therapy Medicine (General) R5-920 |
| spellingShingle |
borneol nanocarrier drug delivery targeting drug resistance tumor therapy Medicine (General) R5-920 Jinxiu Li Jinxiu Li Qian Xie Qian Xie Rong Ma Rong Ma Yong Li Yong Li Jianmei Yuan Jianmei Yuan Mihong Ren Mihong Ren Hongyan Li Hongyan Li Jiajun Wang Jiajun Wang Danni Lu Danni Lu Zhuo Xu Zhuo Xu Jian Wang Jian Wang Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System |
| description |
Borneol, a traditional Chinese medicine, can enhance therapeutic efficacy by guiding the active ingredients to the target site. Reportedly, borneol improves the penetration capacity of the nasal, cornea, transdermal, intestinal, and blood-brain barriers. Although nanotechnology dramatically changed the face of oncology by targeting tumor sites, the efficiency of nanoparticles delivered to tumor sites is very low, with only 0.7% of the total particles delivered. Thus, based on the penetration ability and the inhibition drug efflux of borneol, it was expected to increase the targeting and detention efficacy of drugs into tumor sites in nanocarriers with borneol modification. Borneol modified nanocarriers used to improve drug-targeting has become a research focus in recent years, but few studies in this area, especially in the antitumor application. Hence, this review summarizes the recent development of nanocarriers with borneol modification. We focus on the updated works of improving therapeutic efficacy, reducing toxicity, inhibiting tumor metastasis, reversing multidrug resistance, and enhancing brain targeting to expand their application and provide a reference for further exploration of targeting drug delivery systems for solid tumor treatment. |
| format |
article |
| author |
Jinxiu Li Jinxiu Li Qian Xie Qian Xie Rong Ma Rong Ma Yong Li Yong Li Jianmei Yuan Jianmei Yuan Mihong Ren Mihong Ren Hongyan Li Hongyan Li Jiajun Wang Jiajun Wang Danni Lu Danni Lu Zhuo Xu Zhuo Xu Jian Wang Jian Wang |
| author_facet |
Jinxiu Li Jinxiu Li Qian Xie Qian Xie Rong Ma Rong Ma Yong Li Yong Li Jianmei Yuan Jianmei Yuan Mihong Ren Mihong Ren Hongyan Li Hongyan Li Jiajun Wang Jiajun Wang Danni Lu Danni Lu Zhuo Xu Zhuo Xu Jian Wang Jian Wang |
| author_sort |
Jinxiu Li |
| title |
Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System |
| title_short |
Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System |
| title_full |
Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System |
| title_fullStr |
Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System |
| title_full_unstemmed |
Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System |
| title_sort |
recent progress on the synergistic antitumor effect of a borneol-modified nanocarrier drug delivery system |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/0a41460089944094a44208f9d4086517 |
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